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- W2330389488 abstract "Mouse leukemia cell (L1210) is sensitive to 6-mercaptopurine (6-MP) and does not usually grow in medium containing 0.1 μg/ml of 6-MP. However, cells which could grow in medium containing 0.3 μ/ml of 6-MP were easily obtained at a rate of about 10-5.There were two types of 6-MP resistant strains thus obtained in 0.3 pig/ml of 6-MP; the one was low-resistant strain which could grow in 1 μg/ml of 6-MP but could not in 3 μg/ml, and the other was high-resistant strain which could grow even in 30 μg/ml of 6-MP. Most (96.1 %) of the resistant cells obtained in medium containing 0.3 μg/ml of 6-MP belong to high resistant strain and 3.9% to low-resistant one.The resistance mechamisms of these two strains were not clarified but might be different from each other by the following results;1) Low-resistant strain could grow in HAT medium but high-resistant strain could not.2) The sensitivity of low-resistant strain to 6-MP was increased by the treatment with Levamisole, whereas no change was found in high-resistant strain.3) Reversion to sensitive cell could be observed in the low-resistant strain but not in high-resistant one.4) Only high-resistant cell could obtained from the revertant cell but no low-resistant cell could be obtained." @default.
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- W2330389488 date "1979-01-01" @default.
- W2330389488 modified "2023-10-16" @default.
- W2330389488 title "MERCAPTOPURINE RESISTANT MOUSE LEUKEMIA CELL (L1210)" @default.
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- W2330389488 doi "https://doi.org/10.2974/kmj1951.29.13" @default.
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