FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2330396554> ?p ?o ?g. }

• W2330396554 abstract "Mild cognitive impairment (MCI) is a subclinical cognitive decline in the elderly that increases the risk of conversion to Dementia. Delaying the onset of conversion from normal cognition to MCI has public health relevance by potentially reducing the magnitude of cognitive dysfunction related disability. It has been suggested that cognitive reserve, comprised of IQ and behaviors associated with memory facilitation and problem solving, may delay onset of MCI. Time to onset of MCI may also be associated with the risk factor of the APOE-4 allele. MCI classification criteria is inconsistent across studies, suggesting additional public health need to standardize an accurate method of screening. This study examined the association between cognitive reserve, APOE-4, and time to onset of MCI. Data from the 8 year Gingko Evaluation of Memory Study (GEM) clinical trial were used to examine these aims in a sample of n=2,284 cognitively normal individuals. The GEM MCI classification algorithm was extended over 8 years to examine normal cognition survival. Indicators of cognitive reserve were IQ, average monthly frequency of cognitive reserve behaviors, and number of different cognitive reserve behaviors engaged in each month. APOE-4 presence was defined as having at least one copy of the APOE-4 allele. N=1,226 (53.68%) individuals remained cognitively normal over the eight year followup compared to n=1,058 (46.32%) who developed incident MCI over eight year followup. Incident MCI individuals had significantly higher age (p<0.0001) and education (p=0.0320) at entry and were more likely to be male (p=0.0497), Asian/Pacific Islander, Black, or “Other” identified race (p=0.0078). Incident MCI individuals had significantly lower frequency of reading newspapers (p=0.0228) and solving crosswords (p=0.0301), as well as IQ (p=0.0002). Neither the average monthly frequency of cognitive reserve behaviors (p=0.6662) nor the number of different cognitive reserve behaviors engaged in each month were significantly associated with MCI onset (p=0.7809). Age (p<0.0001), education (p<0.0001), IQ (p<0.0001), and APOE-4 presence (p<0.0001) were significantly associated with time to MCI onset in a Cox proportional hazard model adjusted for age, education, IQ, APOE-4 presence, cognitive reserve behavior frequency, and number of different cognitive reserve behaviors engaged in each month." @default.
• W2330396554 created "2016-06-24" @default.
• W2330396554 creator A5052512927 @default.
• W2330396554 date "2016-01-27" @default.
• W2330396554 modified "2023-09-27" @default.
• W2330396554 title "The association between cognitive reserve and time to conversion from normal cognition to mild cognitive impairment" @default.
• W2330396554 cites W1982697297 @default.
• W2330396554 cites W1998751303 @default.
• W2330396554 cites W2017079501 @default.
• W2330396554 cites W2024430285 @default.
• W2330396554 cites W2061095322 @default.
• W2330396554 cites W2068717875 @default.
• W2330396554 cites W2079057539 @default.
• W2330396554 cites W2117614446 @default.
• W2330396554 cites W2144907160 @default.
• W2330396554 cites W2152284561 @default.
• W2330396554 cites W2152415998 @default.
• W2330396554 cites W2163956698 @default.
• W2330396554 hasPublicationYear "2016" @default.
• W2330396554 type Work @default.
• W2330396554 sameAs 2330396554 @default.
• W2330396554 citedByCount "0" @default.
• W2330396554 crossrefType "journal-article" @default.
• W2330396554 hasAuthorship W2330396554A5052512927 @default.
• W2330396554 hasConcept C113280763 @default.
• W2330396554 hasConcept C118552586 @default.
• W2330396554 hasConcept C126322002 @default.
• W2330396554 hasConcept C15744967 @default.
• W2330396554 hasConcept C169900460 @default.
• W2330396554 hasConcept C185711340 @default.
• W2330396554 hasConcept C2779134260 @default.
• W2330396554 hasConcept C2779483572 @default.
• W2330396554 hasConcept C2984863031 @default.
• W2330396554 hasConcept C2984915365 @default.
• W2330396554 hasConcept C548259974 @default.
• W2330396554 hasConcept C57089818 @default.
• W2330396554 hasConcept C67739388 @default.
• W2330396554 hasConcept C71924100 @default.
• W2330396554 hasConcept C74909509 @default.
• W2330396554 hasConceptScore W2330396554C113280763 @default.
• W2330396554 hasConceptScore W2330396554C118552586 @default.
• W2330396554 hasConceptScore W2330396554C126322002 @default.
• W2330396554 hasConceptScore W2330396554C15744967 @default.
• W2330396554 hasConceptScore W2330396554C169900460 @default.
• W2330396554 hasConceptScore W2330396554C185711340 @default.
• W2330396554 hasConceptScore W2330396554C2779134260 @default.
• W2330396554 hasConceptScore W2330396554C2779483572 @default.
• W2330396554 hasConceptScore W2330396554C2984863031 @default.
• W2330396554 hasConceptScore W2330396554C2984915365 @default.
• W2330396554 hasConceptScore W2330396554C548259974 @default.
• W2330396554 hasConceptScore W2330396554C57089818 @default.
• W2330396554 hasConceptScore W2330396554C67739388 @default.
• W2330396554 hasConceptScore W2330396554C71924100 @default.
• W2330396554 hasConceptScore W2330396554C74909509 @default.
• W2330396554 hasLocation W23303965541 @default.
• W2330396554 hasOpenAccess W2330396554 @default.
• W2330396554 hasPrimaryLocation W23303965541 @default.
• W2330396554 hasRelatedWork W1539680355 @default.
• W2330396554 hasRelatedWork W1997640437 @default.
• W2330396554 hasRelatedWork W1999429226 @default.
• W2330396554 hasRelatedWork W2023302457 @default.
• W2330396554 hasRelatedWork W2078827077 @default.
• W2330396554 hasRelatedWork W2100263792 @default.
• W2330396554 hasRelatedWork W2174497040 @default.
• W2330396554 hasRelatedWork W2182100245 @default.
• W2330396554 hasRelatedWork W2269524143 @default.
• W2330396554 hasRelatedWork W2557432433 @default.
• W2330396554 hasRelatedWork W2580655159 @default.
• W2330396554 hasRelatedWork W2801730028 @default.
• W2330396554 hasRelatedWork W2809561987 @default.
• W2330396554 hasRelatedWork W2885742236 @default.
• W2330396554 hasRelatedWork W2901233191 @default.
• W2330396554 hasRelatedWork W2945235401 @default.
• W2330396554 hasRelatedWork W2947047043 @default.
• W2330396554 hasRelatedWork W3084224213 @default.
• W2330396554 hasRelatedWork W3202952130 @default.
• W2330396554 hasRelatedWork W2603078888 @default.
• W2330396554 isParatext "false" @default.
• W2330396554 isRetracted "false" @default.
• W2330396554 magId "2330396554" @default.
• W2330396554 workType "article" @default.