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- W2330397481 abstract "Non A Non B hepatitis is contentious issue in blood banks It is probably the infection which is most commonly transmitted by transfusion but its very existence was only shown by prospective liver function tests on recipients. Although it occurs worldwide the prevalence reported in different studies varies from as low as 2% to 40% or even higher in a single category of patients (cardiac surgery). The disease is characteristically persistent but there is little data on its morbidity and mortality, either in donor or recipient. It does cause sporadic hepatitis in the community but its natural history is quite unknown. In some countries, ALT tests (and/or anti HBc) are being used to exclude donors regarded as high risk, but this strategy is based on studies performed prior to the advent of AIDS and the consequent changes in the composition of the blood donor population. The policy is expensive, both directly and in terms of the percentage of the take rejected and it is not clear what action should be taken regarding the donors of the rejected units. Some of these questions will be answerable by by retrospective testing of samples from past post transfusion hepatitis studies if the recently described findings of Non A Non B virus, using molecular cloning methods, can be independently validated. However new prospective studies will be needed because of the great changes in transfusion which have occurred in the past decade. The preliminary results of such a new study in Sydney suggest that post transfusion Non A Non B hepatitis is even less prevalent now than before and that there is a significant rate of similar syndrome of persistent ALT elevation in non tranfused patients after surgery. A progress report of this study will be presented at the meeting." @default.
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- W2330397481 date "1990-01-01" @default.
- W2330397481 modified "2023-09-27" @default.
- W2330397481 title "Non A Non B hepatitis" @default.
- W2330397481 doi "https://doi.org/10.1016/s0031-3025(16)36396-6" @default.
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