FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2330414391> ?p ?o ?g. }

• W2330414391 endingPage "606" @default.
• W2330414391 startingPage "597" @default.
• W2330414391 abstract "Aim In a cohort of 298 de-novo renal recipients treated with a standard tacrolimus loading dose of 0.2 mg/kg, the combined effects of the CYP3A5*1, POR*28, and CYP3A4*22 genotypes on early tacrolimus exposure (C0), dose requirements, and achievement of the therapeutic target, C0, were examined. The incidence of clinical events (e.g. acute rejection, diabetes mellitus) was compared between genotypes. Results Fast metabolizers (CYP3A5*1/POR*28T carriers) had two-fold to three-fold higher tacrolimus dose requirements compared with slow metabolizers (CYP3A5*3/*3/CYP3A4*22 carriers) and needed significantly more time to achieve the target tacrolimus C0 of a minimum 10 ng/ml (3.3±1.7 vs. 1.34±0.75 days; P<0.0001). No differences in acute rejection incidence and time to first rejection were observed. Slow metabolizers more frequently had tacrolimus C0 above the target range early after transplantation (70 vs. 13% on day 3); however, this did not translate into a higher incidence of post-transplantation diabetes mellitus or graft dysfunction. Multivariate analyses identified the CYP3A5*1/POR*28/CYP3A4*22 genotype combination as the single strongest determinant of tacrolimus dose requirements throughout the first year, explaining between 24–40% of its variability, whereas recipient age, hematocrit, and delayed graft function were additional nongenetic determinants of tacrolimus dose. Conclusion Combining the CYP3A5*1, POR*28 and CYP3A4*22 genotypes allows partial differentiation of early tacrolimus dose requirements and the time to reach therapeutic target concentrations after transplantation, but without obvious clinical implications. Larger prospective studies need to address the clinical relevance of early combined genotype-based tacrolimus dosing in de-novo renal recipients." @default.
• W2330414391 created "2016-06-24" @default.
• W2330414391 creator A5007986643 @default.
• W2330414391 creator A5025590861 @default.
• W2330414391 creator A5032721362 @default.
• W2330414391 creator A5051240784 @default.
• W2330414391 creator A5064110490 @default.
• W2330414391 date "2014-12-01" @default.
• W2330414391 modified "2023-09-23" @default.
• W2330414391 title "Combined effects of CYP3A5*1, POR*28, and CYP3A4*22 single nucleotide polymorphisms on early concentration-controlled tacrolimus exposure in de-novo renal recipients" @default.
• W2330414391 cites W1567403209 @default.
• W2330414391 cites W1967670996 @default.
• W2330414391 cites W1968180599 @default.
• W2330414391 cites W1969925044 @default.
• W2330414391 cites W1974313161 @default.
• W2330414391 cites W1975638416 @default.
• W2330414391 cites W1978362461 @default.
• W2330414391 cites W1982607095 @default.
• W2330414391 cites W1984463822 @default.
• W2330414391 cites W1986080936 @default.
• W2330414391 cites W2007523308 @default.
• W2330414391 cites W2021775978 @default.
• W2330414391 cites W2024868771 @default.
• W2330414391 cites W2032584539 @default.
• W2330414391 cites W2034728660 @default.
• W2330414391 cites W2054166508 @default.
• W2330414391 cites W2061099365 @default.
• W2330414391 cites W2062385811 @default.
• W2330414391 cites W2064001298 @default.
• W2330414391 cites W2071072708 @default.
• W2330414391 cites W2077782498 @default.
• W2330414391 cites W2080228333 @default.
• W2330414391 cites W2080240185 @default.
• W2330414391 cites W2094260121 @default.
• W2330414391 cites W2098773501 @default.
• W2330414391 cites W2107353400 @default.
• W2330414391 cites W2118094114 @default.
• W2330414391 cites W2120817045 @default.
• W2330414391 cites W2121987020 @default.
• W2330414391 cites W2324831444 @default.
• W2330414391 doi "https://doi.org/10.1097/fpc.0000000000000095" @default.
• W2330414391 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25322286" @default.
• W2330414391 hasPublicationYear "2014" @default.
• W2330414391 type Work @default.
• W2330414391 sameAs 2330414391 @default.
• W2330414391 citedByCount "42" @default.
• W2330414391 countsByYear W23304143912015 @default.
• W2330414391 countsByYear W23304143912016 @default.
• W2330414391 countsByYear W23304143912017 @default.
• W2330414391 countsByYear W23304143912018 @default.
• W2330414391 countsByYear W23304143912019 @default.
• W2330414391 countsByYear W23304143912020 @default.
• W2330414391 countsByYear W23304143912021 @default.
• W2330414391 countsByYear W23304143912022 @default.
• W2330414391 countsByYear W23304143912023 @default.
• W2330414391 crossrefType "journal-article" @default.
• W2330414391 hasAuthorship W2330414391A5007986643 @default.
• W2330414391 hasAuthorship W2330414391A5025590861 @default.
• W2330414391 hasAuthorship W2330414391A5032721362 @default.
• W2330414391 hasAuthorship W2330414391A5051240784 @default.
• W2330414391 hasAuthorship W2330414391A5064110490 @default.
• W2330414391 hasConcept C104317684 @default.
• W2330414391 hasConcept C109650736 @default.
• W2330414391 hasConcept C120665830 @default.
• W2330414391 hasConcept C121332964 @default.
• W2330414391 hasConcept C126322002 @default.
• W2330414391 hasConcept C128057223 @default.
• W2330414391 hasConcept C135763542 @default.
• W2330414391 hasConcept C19831878 @default.
• W2330414391 hasConcept C2780035454 @default.
• W2330414391 hasConcept C2909675724 @default.
• W2330414391 hasConcept C2911091166 @default.
• W2330414391 hasConcept C526171541 @default.
• W2330414391 hasConcept C54355233 @default.
• W2330414391 hasConcept C55775858 @default.
• W2330414391 hasConcept C61511704 @default.
• W2330414391 hasConcept C62231903 @default.
• W2330414391 hasConcept C71924100 @default.
• W2330414391 hasConcept C86803240 @default.
• W2330414391 hasConcept C90924648 @default.
• W2330414391 hasConcept C92137452 @default.
• W2330414391 hasConcept C98274493 @default.
• W2330414391 hasConceptScore W2330414391C104317684 @default.
• W2330414391 hasConceptScore W2330414391C109650736 @default.
• W2330414391 hasConceptScore W2330414391C120665830 @default.
• W2330414391 hasConceptScore W2330414391C121332964 @default.
• W2330414391 hasConceptScore W2330414391C126322002 @default.
• W2330414391 hasConceptScore W2330414391C128057223 @default.
• W2330414391 hasConceptScore W2330414391C135763542 @default.
• W2330414391 hasConceptScore W2330414391C19831878 @default.
• W2330414391 hasConceptScore W2330414391C2780035454 @default.
• W2330414391 hasConceptScore W2330414391C2909675724 @default.
• W2330414391 hasConceptScore W2330414391C2911091166 @default.
• W2330414391 hasConceptScore W2330414391C526171541 @default.
• W2330414391 hasConceptScore W2330414391C54355233 @default.
• W2330414391 hasConceptScore W2330414391C55775858 @default.
• W2330414391 hasConceptScore W2330414391C61511704 @default.
• W2330414391 hasConceptScore W2330414391C62231903 @default.

• next