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• W2330414458 abstract "Analogues of the natural product (-)-arctigenin, an activator of adenosine monophosphate activated protein kinase, were prepared in order to evaluate their effects on 2-deoxyglucose uptake in L6 myotubes and possible use in ameliorating metabolic disorders. Racemic arctigenin 2a was found to display a similar uptake enhancement as does (-)-arctigenin. As a result, the SAR study was conducted utilizing racemic compounds. The structure-activity relationship study led to the discovery of key substitution patterns on the lactone motif that govern 2-deoxyglucose uptake activities. The results show that replacement of the para-hydroxyl group of the C-2 benzyl moiety of arctigenin by Cl has a pronounced effect on uptake activity. Specifically, analogue 2p, which contains the p-Cl substituent, stimulates glucose uptake and fatty acid oxidation in L6 myotubes." @default.
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• W2330414458 date "2015-03-05" @default.
• W2330414458 modified "2023-10-06" @default.
• W2330414458 title "Design and Synthesis of Novel Arctigenin Analogues for the Amelioration of Metabolic Disorders" @default.
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• W2330414458 doi "https://doi.org/10.1021/acsmedchemlett.5b00007" @default.
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