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• W2330436413 abstract "We designed a randomized trial of IC with or without quinine, an agent capable of re­ verting the multi drug resistance (mdr) phenotype, in patients aged s 65 years with high risk MDS. Patients were randomized to receive Mitoxantrone 12mglm2/d d2_5 + AraC Iglm2/12h d'_5' with (Q+) or without (Q) quinine (30mg/kg/day). 131 patients were included. PGP ex­ pression analysis was successfully made in 91 patients and 42 patients (46%) had positive PGP expression. In PGP positive cases, 13 of the 25 (52%) patients who received quinine achieved CR, as compared to 3 of the 17 (18%) patients treated with chemotherapy alone (p=O.02). In PGP negative cases, the CR rate was 35% and 49%, respectively in patients who received quinine or chemotherapy alone (difference not significant). In the 42 PGP • Correspondence and reprint requests: Pr. P. Fenaux, Service des Maladies du Sang, CHU, I place de Verdun, 59037 Lille France. Fax: 33(0)3 20444094; Tel: 33 (0)3 204443 48." @default.
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• W2330436413 date "1999-01-01" @default.
• W2330436413 modified "2023-09-27" @default.
• W2330436413 title "QUININE IMPROVES RESULTS OF INTENSIVE CHEMOTHERAPY (IC) IN MYELODYSPLASTIC SYNDROMES (MDS) EXPRESSING P-GLYCOPROTEIN (PGP) Updated Results of a Randomized Study" @default.
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