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• W2330441485 startingPage "18597" @default.
• W2330441485 abstract "Ironic as it sounds, the pharmaceutical industry is ailing. Despite doubling their R&D expenditures over the past decade, innovator drug companies have struggled to increase their annual drug approval rates. Worse still, candidate attrition rates and development times actually rose during this period. It now costs well in excess of a billion dollars and takes over a decade to discover and develop a new drug. A variety of prognostications have been made regarding the future course that the pharmaceutical industry might take, but none has been as controversial as the suggestion that small-molecule drugs could disappear by 2030. Rest assured that these claims could not be further from the truth. Herein, I outline how biocatalysis and metabolic engineering could drive the next wave of innovation in small-molecule drug discovery. The recent past has witnessed staggering developments in analytical chemistry, genome sequencing and assembly, flow chemistry, chemi- and bioinformatics, metabolic engineering and synthetic chemistry, as well as exponential improvements in the raw computing power that is available for drug research; integrating these parallel innovations into a single platform could translate a vastly higher number of small-molecule drugs to the bedside. I term this integrated approach as “biosynthonics”. Many of its individual elements are already in use drug discovery and development, albeit in a scattered manner, and despite the substantial progress that has occurred in each individual domain, a lot still remains to be achieved if biosynthonics is to become a broad platform for generating focused libraries of natural product-like molecules. It is hoped that this article spurs debate and future collaborations toward achieving these goals, which, if successful, would undoubtedly improve small-molecule R&D productivity." @default.
• W2330441485 created "2016-06-24" @default.
• W2330441485 creator A5052776887 @default.
• W2330441485 date "2014-06-18" @default.
• W2330441485 modified "2023-10-16" @default.
• W2330441485 title "Biosynthonics: Charting the Future Role of Biocatalysis and Metabolic Engineering in Drug Discovery" @default.
• W2330441485 cites W1491585327 @default.
• W2330441485 cites W1541232310 @default.
• W2330441485 cites W1560556066 @default.
• W2330441485 cites W1895993106 @default.
• W2330441485 cites W1965332656 @default.
• W2330441485 cites W1966307175 @default.
• W2330441485 cites W1967681366 @default.
• W2330441485 cites W1968469828 @default.
• W2330441485 cites W1968682237 @default.
• W2330441485 cites W1969487950 @default.
• W2330441485 cites W1970481425 @default.
• W2330441485 cites W1972821149 @default.
• W2330441485 cites W1980662858 @default.
• W2330441485 cites W1985858069 @default.
• W2330441485 cites W1987777080 @default.
• W2330441485 cites W1990925961 @default.
• W2330441485 cites W1992041755 @default.
• W2330441485 cites W1995805296 @default.
• W2330441485 cites W1996629685 @default.
• W2330441485 cites W2003316232 @default.
• W2330441485 cites W2005208748 @default.
• W2330441485 cites W2006197769 @default.
• W2330441485 cites W2008715595 @default.
• W2330441485 cites W2008733674 @default.
• W2330441485 cites W2009291347 @default.
• W2330441485 cites W2023075963 @default.
• W2330441485 cites W2025294451 @default.
• W2330441485 cites W2025948031 @default.
• W2330441485 cites W2028326521 @default.
• W2330441485 cites W2028816469 @default.
• W2330441485 cites W2030211802 @default.
• W2330441485 cites W2031296931 @default.
• W2330441485 cites W2033146918 @default.
• W2330441485 cites W2034645234 @default.
• W2330441485 cites W2036428713 @default.
• W2330441485 cites W2036984750 @default.
• W2330441485 cites W2037026236 @default.
• W2330441485 cites W2037069087 @default.
• W2330441485 cites W2037443039 @default.
• W2330441485 cites W2045798970 @default.
• W2330441485 cites W2046006818 @default.
• W2330441485 cites W2046258407 @default.
• W2330441485 cites W2050754173 @default.
• W2330441485 cites W2053558244 @default.
• W2330441485 cites W2057050140 @default.
• W2330441485 cites W2058211299 @default.
• W2330441485 cites W2059719012 @default.
• W2330441485 cites W2062458432 @default.
• W2330441485 cites W2064073012 @default.
• W2330441485 cites W2065163714 @default.
• W2330441485 cites W2066827579 @default.
• W2330441485 cites W2067833766 @default.
• W2330441485 cites W2068279841 @default.
• W2330441485 cites W2070360032 @default.
• W2330441485 cites W2076915648 @default.
• W2330441485 cites W2077697235 @default.
• W2330441485 cites W2080895748 @default.
• W2330441485 cites W2083110179 @default.
• W2330441485 cites W2083258699 @default.
• W2330441485 cites W2086951287 @default.
• W2330441485 cites W2087993013 @default.
• W2330441485 cites W2088904845 @default.
• W2330441485 cites W2089416959 @default.
• W2330441485 cites W2094639130 @default.
• W2330441485 cites W2098933757 @default.
• W2330441485 cites W2099908928 @default.
• W2330441485 cites W2102754716 @default.
• W2330441485 cites W2104038711 @default.
• W2330441485 cites W2107607807 @default.
• W2330441485 cites W2110485308 @default.
• W2330441485 cites W2111859098 @default.
• W2330441485 cites W2112169196 @default.
• W2330441485 cites W2114393207 @default.
• W2330441485 cites W2116516144 @default.
• W2330441485 cites W2128539991 @default.
• W2330441485 cites W2130839195 @default.
• W2330441485 cites W2135639274 @default.
• W2330441485 cites W2135851057 @default.
• W2330441485 cites W2141474275 @default.
• W2330441485 cites W2143486069 @default.
• W2330441485 cites W2155289933 @default.
• W2330441485 cites W2156779720 @default.
• W2330441485 cites W2159923211 @default.
• W2330441485 cites W2162106505 @default.
• W2330441485 cites W2168059482 @default.
• W2330441485 cites W2206840988 @default.
• W2330441485 cites W2330860891 @default.
• W2330441485 cites W2412606489 @default.
• W2330441485 cites W2505405263 @default.
• W2330441485 cites W2759567918 @default.
• W2330441485 cites W2950124390 @default.
• W2330441485 cites W3175318380 @default.

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