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- W2330481449 abstract "O n a sunny August afternoon, Richard Brimacombe sits on a concrete wall, enjoying the sea breeze blowing off Long Island Sound. Moments earlier, this biochemist from the Max Planck Institute for Molecular Genetics in Berlin had dazzled an audience of molecular biologists with his computer rendition of the ribosome, the cell's protein-producing machine. I'm not a good scientist; don't read the literature and things like that, he says by way of explaining why he works on solving the structure of the ribosome. I need a problem that's like a crossword puzzle [so] can sit in my little room and let the world go Except the world won't go by. A senior scientist accosts him, feeling him out about moving to a different research institute. As that scientist leaves, two young researchers arrange for Brimacombe to send them data about where he thinks the various atoms in the ribosome's core are located. No sooner have they left than a woman from the translational control conference at the Cold Spring Harbor (N.Y.) Laboratory approaches. Tell me, position 1,823 in ribosomal RNA is it important? she demands. Ah, 1,823, where is It's helix 66, about, isn't it? he replies. He tries to recall where that one base out of the 2,904 RNA building blocks he has plotted onto his computer model is located. Why do you ask? Hanna Engelberg-Kulka, a molecular biologist from Hebrew University-Hadassah Medical School in Jerusalem, hesitates. It could be important. Is it exposed? she asks. Brimacombe says he thinks so and offers to check a more detailed diagram so he can let her know for sure later. She leaves, and he shakes his head, perplexed by the attention." @default.
- W2330481449 created "2016-06-24" @default.
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- W2330481449 date "1994-11-05" @default.
- W2330481449 modified "2023-10-17" @default.
- W2330481449 title "Piecing Together the Ribosome" @default.
- W2330481449 doi "https://doi.org/10.2307/3978543" @default.
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