Matches in SemOpenAlex for { <https://semopenalex.org/work/W2330482371> ?p ?o ?g. }
- W2330482371 endingPage "465" @default.
- W2330482371 startingPage "456" @default.
- W2330482371 abstract "Abstract Sessile serrated colon adenoma/polyps (SSA/P) are found during routine screening colonoscopy and may account for 20% to 30% of colon cancers. However, differentiating SSA/Ps from hyperplastic polyps (HP) with little risk of cancer is challenging and complementary molecular markers are needed. In addition, the molecular mechanisms of colon cancer development from SSA/Ps are poorly understood. RNA sequencing (RNA-Seq) was performed on 21 SSA/Ps, 10 HPs, 10 adenomas, 21 uninvolved colon, and 20 control colon specimens. Differential expression and leave-one-out cross-validation methods were used to define a unique gene signature of SSA/Ps. Our SSA/P gene signature was evaluated in colon cancer RNA-Seq data from The Cancer Genome Atlas (TCGA) to identify a subtype of colon cancers that may develop from SSA/Ps. A total of 1,422 differentially expressed genes were found in SSA/Ps relative to controls. Serrated polyposis syndrome (n = 12) and sporadic SSA/Ps (n = 9) exhibited almost complete (96%) gene overlap. A 51-gene panel in SSA/P showed similar expression in a subset of TCGA colon cancers with high microsatellite instability. A smaller 7-gene panel showed high sensitivity and specificity in identifying BRAF-mutant, CpG island methylator phenotype high, and MLH1-silenced colon cancers. We describe a unique gene signature in SSA/Ps that identifies a subset of colon cancers likely to develop through the serrated pathway. These gene panels may be utilized for improved differentiation of SSA/Ps from HPs and provide insights into novel molecular pathways altered in colon cancer arising from the serrated pathway. Cancer Prev Res; 9(6); 456–65. ©2016 AACR." @default.
- W2330482371 created "2016-06-24" @default.
- W2330482371 creator A5004031719 @default.
- W2330482371 creator A5007687972 @default.
- W2330482371 creator A5026851914 @default.
- W2330482371 creator A5029486180 @default.
- W2330482371 creator A5053283545 @default.
- W2330482371 creator A5082070319 @default.
- W2330482371 creator A5090099699 @default.
- W2330482371 date "2016-05-31" @default.
- W2330482371 modified "2023-10-16" @default.
- W2330482371 title "Gene Signature in Sessile Serrated Polyps Identifies Colon Cancer Subtype" @default.
- W2330482371 cites W11057776 @default.
- W2330482371 cites W1529362854 @default.
- W2330482371 cites W1536057578 @default.
- W2330482371 cites W1671617903 @default.
- W2330482371 cites W1678047477 @default.
- W2330482371 cites W1934094702 @default.
- W2330482371 cites W1969231537 @default.
- W2330482371 cites W1970303894 @default.
- W2330482371 cites W1975224807 @default.
- W2330482371 cites W1977065907 @default.
- W2330482371 cites W1978351270 @default.
- W2330482371 cites W1985558567 @default.
- W2330482371 cites W1987225828 @default.
- W2330482371 cites W1993302267 @default.
- W2330482371 cites W1996585050 @default.
- W2330482371 cites W2003396159 @default.
- W2330482371 cites W2006269467 @default.
- W2330482371 cites W2007091966 @default.
- W2330482371 cites W2014117157 @default.
- W2330482371 cites W2019354420 @default.
- W2330482371 cites W2028966442 @default.
- W2330482371 cites W2029342984 @default.
- W2330482371 cites W2031284310 @default.
- W2330482371 cites W2032897100 @default.
- W2330482371 cites W2034801236 @default.
- W2330482371 cites W2036720226 @default.
- W2330482371 cites W2038143310 @default.
- W2330482371 cites W2045933328 @default.
- W2330482371 cites W2062250095 @default.
- W2330482371 cites W2065532397 @default.
- W2330482371 cites W2070632913 @default.
- W2330482371 cites W2071216463 @default.
- W2330482371 cites W2096803057 @default.
- W2330482371 cites W2114843025 @default.
- W2330482371 cites W2115235387 @default.
- W2330482371 cites W2117920692 @default.
- W2330482371 cites W2118017554 @default.
- W2330482371 cites W2144940507 @default.
- W2330482371 cites W2145709967 @default.
- W2330482371 cites W2149441684 @default.
- W2330482371 cites W2149795957 @default.
- W2330482371 cites W2157214221 @default.
- W2330482371 cites W2159495199 @default.
- W2330482371 cites W2161283575 @default.
- W2330482371 cites W2161867610 @default.
- W2330482371 cites W2163830096 @default.
- W2330482371 cites W2165674669 @default.
- W2330482371 cites W2179438025 @default.
- W2330482371 cites W2262414037 @default.
- W2330482371 cites W2333024423 @default.
- W2330482371 doi "https://doi.org/10.1158/1940-6207.capr-15-0363" @default.
- W2330482371 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4941619" @default.
- W2330482371 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27026680" @default.
- W2330482371 hasPublicationYear "2016" @default.
- W2330482371 type Work @default.
- W2330482371 sameAs 2330482371 @default.
- W2330482371 citedByCount "36" @default.
- W2330482371 countsByYear W23304823712016 @default.
- W2330482371 countsByYear W23304823712017 @default.
- W2330482371 countsByYear W23304823712018 @default.
- W2330482371 countsByYear W23304823712019 @default.
- W2330482371 countsByYear W23304823712020 @default.
- W2330482371 countsByYear W23304823712021 @default.
- W2330482371 countsByYear W23304823712022 @default.
- W2330482371 countsByYear W23304823712023 @default.
- W2330482371 crossrefType "journal-article" @default.
- W2330482371 hasAuthorship W2330482371A5004031719 @default.
- W2330482371 hasAuthorship W2330482371A5007687972 @default.
- W2330482371 hasAuthorship W2330482371A5026851914 @default.
- W2330482371 hasAuthorship W2330482371A5029486180 @default.
- W2330482371 hasAuthorship W2330482371A5053283545 @default.
- W2330482371 hasAuthorship W2330482371A5082070319 @default.
- W2330482371 hasAuthorship W2330482371A5090099699 @default.
- W2330482371 hasBestOaLocation W23304823711 @default.
- W2330482371 hasConcept C104317684 @default.
- W2330482371 hasConcept C111425858 @default.
- W2330482371 hasConcept C121608353 @default.
- W2330482371 hasConcept C150194340 @default.
- W2330482371 hasConcept C162317418 @default.
- W2330482371 hasConcept C180754005 @default.
- W2330482371 hasConcept C2779733811 @default.
- W2330482371 hasConcept C2779767149 @default.
- W2330482371 hasConcept C502942594 @default.
- W2330482371 hasConcept C526805850 @default.
- W2330482371 hasConcept C54355233 @default.
- W2330482371 hasConcept C60748783 @default.