Matches in SemOpenAlex for { <https://semopenalex.org/work/W2330484539> ?p ?o ?g. }
- W2330484539 endingPage "5359" @default.
- W2330484539 startingPage "5348" @default.
- W2330484539 abstract "Peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) inhibits skin tumorigenesis through mechanisms that may be dependent on HRAS signaling. The present study examined the hypothesis that PPARβ/δ promotes HRAS-induced senescence resulting in suppression of tumorigenesis. PPARβ/δ expression increased p-ERK and decreased p-AKT activity. Increased p-ERK activity results from the dampened HRAS-induced negative feedback response mediated in part through transcriptional upregulation of RAS guanyl-releasing protein 1 (RASGRP1) by PPARβ/δ. Decreased p-AKT activity results from repression of integrin-linked kinase (ILK) and phosphoinositide-dependent protein kinase-1 (PDPK1) expression. Decreased p-AKT activity in turn promotes cellular senescence through upregulation of p53 and p27 expression. Both over-expression of RASGRP1 and shRNA-mediated knockdown of ILK partially restore cellular senescence in Pparβ/δ-null cells. Higher PPARβ/δ expression is also correlated with increased senescence observed in human benign neurofibromas and colon adenoma lesions in vivo. These results demonstrate that PPARβ/δ promotes senescence to inhibit tumorigenesis and provide new mechanistic insights into HRAS-induced cellular senescence." @default.
- W2330484539 created "2016-06-24" @default.
- W2330484539 creator A5010622208 @default.
- W2330484539 creator A5011233256 @default.
- W2330484539 creator A5034523396 @default.
- W2330484539 creator A5043770377 @default.
- W2330484539 creator A5046458828 @default.
- W2330484539 creator A5073932699 @default.
- W2330484539 creator A5076999950 @default.
- W2330484539 creator A5081069263 @default.
- W2330484539 creator A5088920518 @default.
- W2330484539 date "2013-11-11" @default.
- W2330484539 modified "2023-10-06" @default.
- W2330484539 title "PPARβ/δ promotes HRAS-induced senescence and tumor suppression by potentiating p-ERK and repressing p-AKT signaling" @default.
- W2330484539 cites W1526570055 @default.
- W2330484539 cites W1569152804 @default.
- W2330484539 cites W1882985910 @default.
- W2330484539 cites W1966453709 @default.
- W2330484539 cites W1978737330 @default.
- W2330484539 cites W1984621921 @default.
- W2330484539 cites W1985651419 @default.
- W2330484539 cites W1986449189 @default.
- W2330484539 cites W1991320113 @default.
- W2330484539 cites W1996009633 @default.
- W2330484539 cites W1997032085 @default.
- W2330484539 cites W2001353514 @default.
- W2330484539 cites W2001604240 @default.
- W2330484539 cites W2004806132 @default.
- W2330484539 cites W2008962463 @default.
- W2330484539 cites W2010345740 @default.
- W2330484539 cites W2012277808 @default.
- W2330484539 cites W2013885821 @default.
- W2330484539 cites W2014299623 @default.
- W2330484539 cites W2015261107 @default.
- W2330484539 cites W2019050619 @default.
- W2330484539 cites W2019086311 @default.
- W2330484539 cites W2027217537 @default.
- W2330484539 cites W2027329429 @default.
- W2330484539 cites W2034131665 @default.
- W2330484539 cites W2050245934 @default.
- W2330484539 cites W2060632243 @default.
- W2330484539 cites W2063864717 @default.
- W2330484539 cites W2067117191 @default.
- W2330484539 cites W2075374049 @default.
- W2330484539 cites W2078323658 @default.
- W2330484539 cites W2087100775 @default.
- W2330484539 cites W2087404852 @default.
- W2330484539 cites W2088293068 @default.
- W2330484539 cites W2093221417 @default.
- W2330484539 cites W2095229835 @default.
- W2330484539 cites W2095639791 @default.
- W2330484539 cites W2102760130 @default.
- W2330484539 cites W2104289043 @default.
- W2330484539 cites W2105566302 @default.
- W2330484539 cites W2109303707 @default.
- W2330484539 cites W2116405752 @default.
- W2330484539 cites W2121014269 @default.
- W2330484539 cites W2121147154 @default.
- W2330484539 cites W2121325716 @default.
- W2330484539 cites W2127488145 @default.
- W2330484539 cites W2128124648 @default.
- W2330484539 cites W2131078803 @default.
- W2330484539 cites W2135056923 @default.
- W2330484539 cites W2138756913 @default.
- W2330484539 cites W2141425188 @default.
- W2330484539 cites W2141727424 @default.
- W2330484539 cites W2143894217 @default.
- W2330484539 cites W2144402710 @default.
- W2330484539 cites W2146157811 @default.
- W2330484539 cites W2148179658 @default.
- W2330484539 cites W2153349010 @default.
- W2330484539 cites W2153617345 @default.
- W2330484539 cites W2155311724 @default.
- W2330484539 cites W2157586477 @default.
- W2330484539 cites W2161784786 @default.
- W2330484539 cites W2162178319 @default.
- W2330484539 cites W2162981565 @default.
- W2330484539 cites W2168451979 @default.
- W2330484539 cites W4252961770 @default.
- W2330484539 doi "https://doi.org/10.1038/onc.2013.477" @default.
- W2330484539 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4017002" @default.
- W2330484539 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24213576" @default.
- W2330484539 hasPublicationYear "2013" @default.
- W2330484539 type Work @default.
- W2330484539 sameAs 2330484539 @default.
- W2330484539 citedByCount "37" @default.
- W2330484539 countsByYear W23304845392014 @default.
- W2330484539 countsByYear W23304845392015 @default.
- W2330484539 countsByYear W23304845392016 @default.
- W2330484539 countsByYear W23304845392017 @default.
- W2330484539 countsByYear W23304845392018 @default.
- W2330484539 countsByYear W23304845392019 @default.
- W2330484539 countsByYear W23304845392020 @default.
- W2330484539 countsByYear W23304845392021 @default.
- W2330484539 countsByYear W23304845392022 @default.
- W2330484539 countsByYear W23304845392023 @default.
- W2330484539 crossrefType "journal-article" @default.
- W2330484539 hasAuthorship W2330484539A5010622208 @default.