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- W2330484831 abstract "Various methanesulfonic acid derivatives of four sulfonamides, which are represented generally as R'NHSO2C6H5NHCHRSO3Na wer esynthesized and their hydrolysis rates in vitro and pharmacokinetics of blood concentration change in rabbit were investigated. When R is H the hydrolysis rate is so slow that the pharmacological activity of parental sulfonamide can not be expected. When R is alkyl, phenyl or HOCH2 (CHOH)4 the derivative has fast hydrolysis rate which may promise good availability of parental sulfonamide. The effect of R on hydrolysis rate was elucidated by linear free energy relationship. The dissociation of sulfonamide group hastens the hydrolysis. Dynamic process of appearance and disappearance of parental sulfonamide in blood was quantitatively explained by a scheme which assumes two compartment models for both of the derivative and parental sulfonamide respectively." @default.
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- W2330484831 date "1972-01-01" @default.
- W2330484831 modified "2023-09-23" @default.
- W2330484831 title "Methanesulfonic Acid Derivative of Sulfonamides. I. Hydrolysis Rate in Vitro and Pharmacokinetics in Vivo" @default.
- W2330484831 doi "https://doi.org/10.1248/cpb.20.863" @default.
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