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- W2330485540 abstract "In humans an inherited deficiency of the enzyme purine nucleoside Phosphorylase (PNP; EC 2.4.2.1) is associated with a T cell deficiency and apparently normal B cells (1,2). Although a deficiency of PNP is present in all cells of deficient individuals, only the cells within the T lymphocyte lineage are affected. The immunodeficiency state associated with PNP deficiency is thought to arise from block(s) in T lymphocyte differentiation resulting from the accumulation of toxic metabolites of the enzyme’s substrate(s) (3-5)." @default.
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- W2330485540 date "1986-01-01" @default.
- W2330485540 modified "2023-09-25" @default.
- W2330485540 title "The Effects of PNP Inhibition on Rat Lymphoid Cell Populations" @default.
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- W2330485540 doi "https://doi.org/10.1007/978-1-4684-1248-2_67" @default.
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