FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2330486510> ?p ?o ?g. }

• W2330486510 endingPage "H746" @default.
• W2330486510 startingPage "H738" @default.
• W2330486510 abstract "SK channels are upregulated in human patients and animal models of heart failure (HF). However, their activation mechanism and function in ventricular myocytes remain poorly understood. We aim to test the hypotheses that activation of SK channels in ventricular myocytes requires Ca(2+) release from sarcoplasmic reticulum (SR) and that SK currents contribute to reducing triggered activity. SK2 channels were overexpressed in adult rat ventricular myocytes using adenovirus gene transfer. Simultaneous patch clamp and confocal Ca(2+) imaging experiments in SK2-overexpressing cells demonstrated that depolarizations resulted in Ca(2+)-dependent outward currents sensitive to SK inhibitor apamin. SR Ca(2+) release induced by rapid application of 10 mM caffeine evoked repolarizing SK currents, whereas complete depletion of SR Ca(2+) content eliminated SK currents in response to depolarizations, despite intact Ca(2+) influx through L-type Ca(2+) channels. Furthermore, voltage-clamp experiments showed that SK channels can be activated by global spontaneous SR Ca(2+) release events Ca(2+) waves (SCWs). Current-clamp experiments revealed that SK overexpression reduces the amplitude of delayed afterdepolarizations (DADs) resulting from SCWs and shortens action potential duration. Immunolocalization studies showed that overexpressed SK channels are distributed both at external sarcolemmal membranes and along the Z-lines, resembling the distribution of endogenous SK channels. In summary, SR Ca(2+) release is both necessary and sufficient for the activation of SK channels in rat ventricular myocytes. SK currents contribute to repolarization during action potentials and attenuate DADs driven by SCWs. Thus SK upregulation in HF may have an anti-arrhythmic effect by reducing triggered activity." @default.
• W2330486510 created "2016-06-24" @default.
• W2330486510 creator A5009871577 @default.
• W2330486510 creator A5011616550 @default.
• W2330486510 creator A5011626611 @default.
• W2330486510 creator A5074613232 @default.
• W2330486510 creator A5075692221 @default.
• W2330486510 creator A5083671106 @default.
• W2330486510 date "2014-03-01" @default.
• W2330486510 modified "2023-09-29" @default.
• W2330486510 title "Sarcoplasmic reticulum Ca²⁺ release is both necessary and sufficient for SK channel activation in ventricular myocytes" @default.
• W2330486510 cites W1490915066 @default.
• W2330486510 cites W1971635966 @default.
• W2330486510 cites W1973438087 @default.
• W2330486510 cites W1988452782 @default.
• W2330486510 cites W2022607662 @default.
• W2330486510 cites W2042670053 @default.
• W2330486510 cites W2042998312 @default.
• W2330486510 cites W2043511431 @default.
• W2330486510 cites W2046073283 @default.
• W2330486510 cites W2051023125 @default.
• W2330486510 cites W2053387749 @default.
• W2330486510 cites W2054773469 @default.
• W2330486510 cites W2060727804 @default.
• W2330486510 cites W2068508510 @default.
• W2330486510 cites W2069569950 @default.
• W2330486510 cites W2079697827 @default.
• W2330486510 cites W2090116945 @default.
• W2330486510 cites W2091572573 @default.
• W2330486510 cites W2093869205 @default.
• W2330486510 cites W2100414478 @default.
• W2330486510 cites W2113240783 @default.
• W2330486510 cites W2114130324 @default.
• W2330486510 cites W2123374731 @default.
• W2330486510 cites W2125058889 @default.
• W2330486510 cites W2131098465 @default.
• W2330486510 cites W2136821886 @default.
• W2330486510 cites W2138004203 @default.
• W2330486510 cites W2139510937 @default.
• W2330486510 cites W2146357327 @default.
• W2330486510 cites W2146629694 @default.
• W2330486510 cites W2148056676 @default.
• W2330486510 cites W2148204431 @default.
• W2330486510 cites W2152124147 @default.
• W2330486510 cites W2152145499 @default.
• W2330486510 cites W2159441016 @default.
• W2330486510 cites W2159453909 @default.
• W2330486510 cites W2160430916 @default.
• W2330486510 cites W2161163873 @default.
• W2330486510 cites W2409473863 @default.
• W2330486510 cites W2548555003 @default.
• W2330486510 cites W4293179290 @default.
• W2330486510 doi "https://doi.org/10.1152/ajpheart.00621.2013" @default.
• W2330486510 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3949063" @default.
• W2330486510 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24381116" @default.
• W2330486510 hasPublicationYear "2014" @default.
• W2330486510 type Work @default.
• W2330486510 sameAs 2330486510 @default.
• W2330486510 citedByCount "43" @default.
• W2330486510 countsByYear W23304865102014 @default.
• W2330486510 countsByYear W23304865102015 @default.
• W2330486510 countsByYear W23304865102016 @default.
• W2330486510 countsByYear W23304865102017 @default.
• W2330486510 countsByYear W23304865102018 @default.
• W2330486510 countsByYear W23304865102019 @default.
• W2330486510 countsByYear W23304865102020 @default.
• W2330486510 countsByYear W23304865102021 @default.
• W2330486510 countsByYear W23304865102022 @default.
• W2330486510 countsByYear W23304865102023 @default.
• W2330486510 crossrefType "journal-article" @default.
• W2330486510 hasAuthorship W2330486510A5009871577 @default.
• W2330486510 hasAuthorship W2330486510A5011616550 @default.
• W2330486510 hasAuthorship W2330486510A5011626611 @default.
• W2330486510 hasAuthorship W2330486510A5074613232 @default.
• W2330486510 hasAuthorship W2330486510A5075692221 @default.
• W2330486510 hasAuthorship W2330486510A5083671106 @default.
• W2330486510 hasBestOaLocation W23304865102 @default.
• W2330486510 hasConcept C104317684 @default.
• W2330486510 hasConcept C12554922 @default.
• W2330486510 hasConcept C126322002 @default.
• W2330486510 hasConcept C127561419 @default.
• W2330486510 hasConcept C134018914 @default.
• W2330486510 hasConcept C146403970 @default.
• W2330486510 hasConcept C147944092 @default.
• W2330486510 hasConcept C158617107 @default.
• W2330486510 hasConcept C181911157 @default.
• W2330486510 hasConcept C185263204 @default.
• W2330486510 hasConcept C185592680 @default.
• W2330486510 hasConcept C207200792 @default.
• W2330486510 hasConcept C2776919887 @default.
• W2330486510 hasConcept C55493867 @default.
• W2330486510 hasConcept C71924100 @default.
• W2330486510 hasConcept C83743174 @default.
• W2330486510 hasConcept C86803240 @default.
• W2330486510 hasConceptScore W2330486510C104317684 @default.
• W2330486510 hasConceptScore W2330486510C12554922 @default.
• W2330486510 hasConceptScore W2330486510C126322002 @default.
• W2330486510 hasConceptScore W2330486510C127561419 @default.

• next