FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2330486927> ?p ?o ?g. }

• W2330486927 abstract "Malaria is a parasite infection affecting millions of people worldwide. Even though progresses in prevention and treatment have been developed, 198 million cases of malaria occurred in 2013, resulting in 584000 estimated deaths. 90% of all malaria deaths occurred in Africa, mostly among children under the age of five. This article aims to review malaria’s history, epidemiology and current treatments, with a particular focus on the potential of molecular farming that use metabolic engineering in plants as effective anti-malarial solution. Malaria indeed represents an example of how a health problem on one hand, may eventually influence the proper development of a country due to the burden of the disease, and on the other hand, constitutes an opportunity for lucrative business of diverse stakeholders. In contrast, plant biofarming is here proposed as a sustainable alternative for the production not only of natural herbal repellents used for malaria prevention but also for the production of sustainable anti-malarial drugs like artemisinin used for primary parasite infection treatments. Artemisinin, a sesquiterpene lactone, is a natural anti-malarial compound that can be found in Artemisia annua plant. However, the low concentration of artemisinin in plant makes this molecule relatively expensive and difficult to meet the worldwide demand of Artemisinin Combination Therapies, especially for economically disadvantaged people in developing countries. The biosynthetic pathway of artemisinin, a process that only takes place in glandular secretory trichomes of A. annua, is relatively well elucidated, and significant efforts using plant genetic engineering have been made to increase the production of this compound. These include studies on diverse transcription factors, which all have been shown to regulate artemisinin genetic pathway and other biological processes. Therefore, genetic manipulation of these genes may be used as a cost-effective potential way for the synthesis and production of medicines against the malaria parasite. Finally, this article will also discuss two risks factors that already affect the fight against malaria. In first place, the onset and progressive development of anti-malarial drug resistance; secondly, the potential and underestimated impact of migrations and global climate changes on the spread of the disease in currently malaria-free countries." @default.
• W2330486927 created "2016-06-24" @default.
• W2330486927 creator A5003240385 @default.
• W2330486927 creator A5021122267 @default.
• W2330486927 creator A5083611027 @default.
• W2330486927 date "2016-03-18" @default.
• W2330486927 modified "2023-10-14" @default.
• W2330486927 title "Molecular Farming in Artemisia annua, a Promising Approach to Improve Anti-malarial Drug Production" @default.
• W2330486927 cites W1000663807 @default.
• W2330486927 cites W1185126547 @default.
• W2330486927 cites W1422595185 @default.
• W2330486927 cites W1529284100 @default.
• W2330486927 cites W1557261629 @default.
• W2330486927 cites W1564382962 @default.
• W2330486927 cites W1571265670 @default.
• W2330486927 cites W1603377201 @default.
• W2330486927 cites W1669895398 @default.
• W2330486927 cites W1719348349 @default.
• W2330486927 cites W1780982862 @default.
• W2330486927 cites W1784128304 @default.
• W2330486927 cites W1887890652 @default.
• W2330486927 cites W1925400499 @default.
• W2330486927 cites W1967648518 @default.
• W2330486927 cites W1969427904 @default.
• W2330486927 cites W1969962785 @default.
• W2330486927 cites W1971385421 @default.
• W2330486927 cites W1973603244 @default.
• W2330486927 cites W1975946680 @default.
• W2330486927 cites W1981404580 @default.
• W2330486927 cites W1982706578 @default.
• W2330486927 cites W1983332251 @default.
• W2330486927 cites W1984669077 @default.
• W2330486927 cites W1986917736 @default.
• W2330486927 cites W1987274357 @default.
• W2330486927 cites W1988086615 @default.
• W2330486927 cites W1988601884 @default.
• W2330486927 cites W1988722330 @default.
• W2330486927 cites W1990226486 @default.
• W2330486927 cites W1991174531 @default.
• W2330486927 cites W1991394302 @default.
• W2330486927 cites W1992324215 @default.
• W2330486927 cites W1992362149 @default.
• W2330486927 cites W1993122840 @default.
• W2330486927 cites W1994684530 @default.
• W2330486927 cites W1994976478 @default.
• W2330486927 cites W1995685700 @default.
• W2330486927 cites W1995764868 @default.
• W2330486927 cites W1996295656 @default.
• W2330486927 cites W1998325904 @default.
• W2330486927 cites W2004440654 @default.
• W2330486927 cites W2008986700 @default.
• W2330486927 cites W2009914684 @default.
• W2330486927 cites W2010067521 @default.
• W2330486927 cites W2010367299 @default.
• W2330486927 cites W2010387696 @default.
• W2330486927 cites W2011894230 @default.
• W2330486927 cites W2013888145 @default.
• W2330486927 cites W2014392076 @default.
• W2330486927 cites W2014709803 @default.
• W2330486927 cites W2014968469 @default.
• W2330486927 cites W2015823022 @default.
• W2330486927 cites W2016348993 @default.
• W2330486927 cites W2019281554 @default.
• W2330486927 cites W2021482850 @default.
• W2330486927 cites W2022786242 @default.
• W2330486927 cites W2023533798 @default.
• W2330486927 cites W2024078814 @default.
• W2330486927 cites W2026254413 @default.
• W2330486927 cites W2027634352 @default.
• W2330486927 cites W2028074179 @default.
• W2330486927 cites W2033812623 @default.
• W2330486927 cites W2034778509 @default.
• W2330486927 cites W2038023315 @default.
• W2330486927 cites W2039894471 @default.
• W2330486927 cites W2040713555 @default.
• W2330486927 cites W2042116011 @default.
• W2330486927 cites W2043551820 @default.
• W2330486927 cites W2043555381 @default.
• W2330486927 cites W2045037263 @default.
• W2330486927 cites W2045115500 @default.
• W2330486927 cites W2048267329 @default.
• W2330486927 cites W2049016946 @default.
• W2330486927 cites W2050928792 @default.
• W2330486927 cites W2052373849 @default.
• W2330486927 cites W2053535190 @default.
• W2330486927 cites W2056337181 @default.
• W2330486927 cites W2057106493 @default.
• W2330486927 cites W2057652073 @default.
• W2330486927 cites W2057823601 @default.
• W2330486927 cites W2057870931 @default.
• W2330486927 cites W2058639789 @default.
• W2330486927 cites W2058774793 @default.
• W2330486927 cites W2061459669 @default.
• W2330486927 cites W2062051365 @default.
• W2330486927 cites W2062496803 @default.
• W2330486927 cites W2064004254 @default.
• W2330486927 cites W2064855181 @default.
• W2330486927 cites W2064909918 @default.
• W2330486927 cites W2068888873 @default.
• W2330486927 cites W2069437402 @default.

• next