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- W2330487219 abstract "Two lanostane triterpenes, 3<i>β</i>-hydroxylanosta-9,24-dien-21-oic acid (<b>1</b>) and methyl-3<i>β</i>-hydroxylanosta-9,24-dien-21-oate (<b>2</b>), were isolated from the stem bark of <i>Protorhus longifolia</i>. Their structures were deduced on the basis of spectroscopic analysis (NMR, HRMS, IR). This study investigated the <i>in vitro</i> anti-adipogenic activity of the two triterpenes. Their inhibitory activity was evaluated on selected lipid digestive enzymes (pancreatic lipase and cholesterol esterase). The inhibitory activity of the compounds on hormone-sensitive lipase and their ability to bind bile acids were also evaluated. The effect of the compounds on glucose uptake in C2C12 muscle cells and 3T3-L1 adipocytes, and on triglyceride accumulation in 3T3-L1 adipocytes was investigated. The triterpenes effectively inhibited the activities of the enzymes with IC<sub>50</sub> values ranging from 0.04 to 0.31 mg/mL. The compounds showed a high affinity for secondary bile acids. Both compounds stimulated glucose uptake in C2C12 muscle cells and 3T3-L1 adipocytes. Compound <b>1</b> significantly reduced triglyceride accumulation in mature differentiated 3T3-L1 adipocytes. It is apparent that these lanostane triterpenes enhance glucose uptake and suppress adipogenesis, which together with their inhibitory effects on lipid digestive enzymes suggests that they have antihyperlipidemic potential." @default.
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- W2330487219 date "2014-11-11" @default.
- W2330487219 modified "2023-10-16" @default.
- W2330487219 title "In Vitro Antihyperlipidemic Potential of Triterpenes from Stem Bark of Protorhus longifolia" @default.
- W2330487219 doi "https://doi.org/10.1055/s-0034-1383262" @default.
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