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• W2330487314 endingPage "C520" @default.
• W2330487314 startingPage "C508" @default.
• W2330487314 abstract "Rett syndrome is an autism-spectrum disorder resulting from mutations to the X-linked gene, methyl-CpG binding protein 2 (MeCP2), which causes abnormalities in many systems. It is possible that the body may develop certain compensatory mechanisms to alleviate the abnormalities. The norepinephrine system originating mainly in the locus coeruleus (LC) is defective in Rett syndrome and Mecp2-null mice. LC neurons are subject to modulation by GABA, glutamate, and acetylcholine (ACh), providing an ideal system to test the compensatory hypothesis. Here we show evidence for potential compensatory modulation of LC neurons by post- and presynaptic ACh inputs. We found that the postsynaptic currents of nicotinic ACh receptors (nAChR) were smaller in amplitude and longer in decay time in the Mecp2-null mice than in the wild type. Single-cell PCR analysis showed a decrease in the expression of α 3 -, α 4 -, α 7 -, and β 3 -subunits and an increase in the α 5 - and α 6 -subunits in the mutant mice. The α 5 -subunit was present in many of the LC neurons with slow-decay nAChR currents. The nicotinic modulation of spontaneous GABA A -ergic inhibitory postsynaptic currents in LC neurons was enhanced in Mecp2-null mice. In contrast, the nAChR manipulation of glutamatergic input to LC neurons was unaffected in both groups of mice. Our current-clamp studies showed that the modulation of LC neurons by ACh input was reduced moderately in Mecp2-null mice, despite the major decrease in nAChR currents, suggesting possible compensatory processes may take place, thus reducing the defects to a lesser extent in LC neurons." @default.
• W2330487314 created "2016-06-24" @default.
• W2330487314 creator A5034297090 @default.
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• W2330487314 creator A5057339074 @default.
• W2330487314 creator A5061702017 @default.
• W2330487314 creator A5071500622 @default.
• W2330487314 date "2014-09-15" @default.
• W2330487314 modified "2023-10-07" @default.
• W2330487314 title "Alterations in the cholinergic system of brain stem neurons in a mouse model of Rett syndrome" @default.
• W2330487314 cites W1493574533 @default.
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• W2330487314 cites W1513275708 @default.
• W2330487314 cites W1533351594 @default.
• W2330487314 cites W1593696547 @default.
• W2330487314 cites W1934489743 @default.
• W2330487314 cites W1967180688 @default.
• W2330487314 cites W1970709955 @default.
• W2330487314 cites W1978127185 @default.
• W2330487314 cites W1978520601 @default.
• W2330487314 cites W1982558275 @default.
• W2330487314 cites W1986501580 @default.
• W2330487314 cites W1987919010 @default.
• W2330487314 cites W1988072680 @default.
• W2330487314 cites W1990157377 @default.
• W2330487314 cites W1994313279 @default.
• W2330487314 cites W1995428553 @default.
• W2330487314 cites W1998448281 @default.
• W2330487314 cites W2004730076 @default.
• W2330487314 cites W2017748409 @default.
• W2330487314 cites W2017990561 @default.
• W2330487314 cites W2021996855 @default.
• W2330487314 cites W2022134477 @default.
• W2330487314 cites W2026727387 @default.
• W2330487314 cites W2027582959 @default.
• W2330487314 cites W2029078782 @default.
• W2330487314 cites W2036581055 @default.
• W2330487314 cites W2037696034 @default.
• W2330487314 cites W2044246406 @default.
• W2330487314 cites W2044595919 @default.
• W2330487314 cites W2045042214 @default.
• W2330487314 cites W2046590157 @default.
• W2330487314 cites W2048273592 @default.
• W2330487314 cites W2052897978 @default.
• W2330487314 cites W2056725005 @default.
• W2330487314 cites W2059320092 @default.
• W2330487314 cites W2062976968 @default.
• W2330487314 cites W2063610145 @default.
• W2330487314 cites W2064612198 @default.
• W2330487314 cites W2068327049 @default.
• W2330487314 cites W2069194632 @default.
• W2330487314 cites W2069273975 @default.
• W2330487314 cites W2079933139 @default.
• W2330487314 cites W2088228824 @default.
• W2330487314 cites W2088996542 @default.
• W2330487314 cites W2089202291 @default.
• W2330487314 cites W2092597282 @default.
• W2330487314 cites W2104027449 @default.
• W2330487314 cites W2106688439 @default.
• W2330487314 cites W2108921991 @default.
• W2330487314 cites W2114897252 @default.
• W2330487314 cites W2115750269 @default.
• W2330487314 cites W2122188465 @default.
• W2330487314 cites W2125837222 @default.
• W2330487314 cites W2129032286 @default.
• W2330487314 cites W2136585162 @default.
• W2330487314 cites W2137751464 @default.
• W2330487314 cites W2138024978 @default.
• W2330487314 cites W2144944542 @default.
• W2330487314 cites W2146391841 @default.
• W2330487314 cites W2147123664 @default.
• W2330487314 cites W2150585160 @default.
• W2330487314 cites W2152020947 @default.
• W2330487314 cites W2159733258 @default.
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• W2330487314 cites W2165978081 @default.
• W2330487314 cites W2166403013 @default.
• W2330487314 cites W2168415226 @default.
• W2330487314 cites W2323622483 @default.
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• W2330487314 doi "https://doi.org/10.1152/ajpcell.00035.2014" @default.
• W2330487314 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4166737" @default.
• W2330487314 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25009110" @default.
• W2330487314 hasPublicationYear "2014" @default.
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