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• W2330501063 abstract "Objective To characterize the effects of deafening and subsequent treatment with brain-derived neurotrophic factor (BDNF) on the peripheral processes (PPs) of spiral ganglion cells (SGCs) in guinea pigs. Background BDNF may prevent degeneration of neural structures after loss of hair cells with possible relevance for cochlear implant candidates. Methods Guinea pigs were deafened with a combination of kanamycin and furosemide. Two weeks after deafening, intracochlear BDNF treatment was started with osmotic pumps for 4 weeks. Two weeks after cessation of BDNF treatment, the cochleae were analyzed. PPs were counted and morphologically characterized with respect to myelination, size, and shape. Results Deafening reduced the number of PPs. We found that BDNF treatment, started 2 weeks after deafening, significantly reduced this degenerative effect. The remaining processes showed an altered morphology; compared with normal, the size was reduced in deafened untreated animals and increased in BDNF-treated animals. The myelin sheath seemed thinner in BDNF-treated animals. Conclusion We conclude that BDNF has potential as an agent that can improve the interface between cochlear implants and the auditory periphery." @default.
• W2330501063 created "2016-06-24" @default.
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• W2330501063 date "2013-04-01" @default.
• W2330501063 modified "2023-10-10" @default.
• W2330501063 title "The Peripheral Processes of Spiral Ganglion Cells After Intracochlear Application of Brain-Derived Neurotrophic Factor in Deafened Guinea Pigs" @default.
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• W2330501063 doi "https://doi.org/10.1097/mao.0b013e31828687b1" @default.
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