FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2330504702> ?p ?o ?g. }

• W2330504702 endingPage "1206" @default.
• W2330504702 startingPage "1198" @default.
• W2330504702 abstract "Insulin is a commonly used protein for studies of amyloidogenesis. There are a few insulin analogues with different pharmacokinetic characteristics, in particular the onset and duration of action. One of them is LysPro insulin. The behavior of LysPro insulin in the process of amyloid formation has not been studied in detail yet. To quantitatively investigate the differences between insulin and LysPro insulin in the aggregation reaction, we used thioflavin T fluorescence assay, electron microscopy, X-ray diffraction methods, and theoretical modeling. Kinetic experimental data for both insulin samples demonstrated the increase of the lag-time for LysPro insulin at low concentrations of monomers, particularly at 2 and 4 mg/mL, which corresponds to the pharmaceutical concentration. However, the morphology of insulin and LysPro insulin fibrils and their X-ray diffraction patterns is identical. Mature fibrils reach 10–12 μm in length and about 3–4 nm in diameter. The obtained analytical solution allow us to determine the sizes of the primary and secondary nuclei from the experimentally obtained concentration dependences of the time of growth and the ratio of the lag-time duration to the time of growth of amyloid protofibrils. In the case of insulin and LysPro insulin, we have exponential growth of amyloid protofibrils following the “bifurcation + lateral growth” scenario. In accord with the developed theory and the experimental data, we obtained that the size of the primary nucleus is equal to one monomer and the size of the secondary nucleus is zero in both insulin and LysPro insulin." @default.
• W2330504702 created "2016-06-24" @default.
• W2330504702 creator A5016891775 @default.
• W2330504702 creator A5023828983 @default.
• W2330504702 creator A5025073972 @default.
• W2330504702 creator A5045067748 @default.
• W2330504702 creator A5061348764 @default.
• W2330504702 creator A5063628201 @default.
• W2330504702 creator A5075273559 @default.
• W2330504702 creator A5085401007 @default.
• W2330504702 date "2014-01-24" @default.
• W2330504702 modified "2023-10-10" @default.
• W2330504702 title "How to Determine the Size of Folding Nuclei of Protofibrils from the Concentration Dependence of the Rate and Lag-Time of Aggregation. II. Experimental Application for Insulin and LysPro Insulin: Aggregation Morphology, Kinetics, and Sizes of Nuclei" @default.
• W2330504702 cites W1481393922 @default.
• W2330504702 cites W1489708565 @default.
• W2330504702 cites W1564193520 @default.
• W2330504702 cites W1964161207 @default.
• W2330504702 cites W1966895081 @default.
• W2330504702 cites W1971515801 @default.
• W2330504702 cites W1972798923 @default.
• W2330504702 cites W1984729685 @default.
• W2330504702 cites W1985563927 @default.
• W2330504702 cites W1986029555 @default.
• W2330504702 cites W1988478867 @default.
• W2330504702 cites W1990712184 @default.
• W2330504702 cites W1991847901 @default.
• W2330504702 cites W2001363066 @default.
• W2330504702 cites W2003650369 @default.
• W2330504702 cites W2005212584 @default.
• W2330504702 cites W2008289288 @default.
• W2330504702 cites W2010462701 @default.
• W2330504702 cites W2014571034 @default.
• W2330504702 cites W2015519486 @default.
• W2330504702 cites W2018880174 @default.
• W2330504702 cites W2023073798 @default.
• W2330504702 cites W2027616961 @default.
• W2330504702 cites W2030325989 @default.
• W2330504702 cites W2031111535 @default.
• W2330504702 cites W2035105430 @default.
• W2330504702 cites W2038913139 @default.
• W2330504702 cites W2043761562 @default.
• W2330504702 cites W2051301360 @default.
• W2330504702 cites W2053125342 @default.
• W2330504702 cites W2058804545 @default.
• W2330504702 cites W2067314188 @default.
• W2330504702 cites W2076892004 @default.
• W2330504702 cites W2078640994 @default.
• W2330504702 cites W2081528927 @default.
• W2330504702 cites W2083554922 @default.
• W2330504702 cites W2094881767 @default.
• W2330504702 cites W2096425372 @default.
• W2330504702 cites W2101614182 @default.
• W2330504702 cites W2117327696 @default.
• W2330504702 cites W2121753059 @default.
• W2330504702 cites W2121852043 @default.
• W2330504702 cites W2125365329 @default.
• W2330504702 cites W2134178829 @default.
• W2330504702 cites W2135007733 @default.
• W2330504702 cites W2135861788 @default.
• W2330504702 cites W2152333414 @default.
• W2330504702 cites W2159170884 @default.
• W2330504702 cites W2165186407 @default.
• W2330504702 cites W2168290713 @default.
• W2330504702 cites W2315228289 @default.
• W2330504702 cites W2321632516 @default.
• W2330504702 cites W2322540009 @default.
• W2330504702 cites W2326329626 @default.
• W2330504702 cites W4237702143 @default.
• W2330504702 doi "https://doi.org/10.1021/jp4083568" @default.
• W2330504702 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24428561" @default.
• W2330504702 hasPublicationYear "2014" @default.
• W2330504702 type Work @default.
• W2330504702 sameAs 2330504702 @default.
• W2330504702 citedByCount "23" @default.
• W2330504702 countsByYear W23305047022015 @default.
• W2330504702 countsByYear W23305047022016 @default.
• W2330504702 countsByYear W23305047022018 @default.
• W2330504702 countsByYear W23305047022019 @default.
• W2330504702 countsByYear W23305047022020 @default.
• W2330504702 countsByYear W23305047022021 @default.
• W2330504702 countsByYear W23305047022022 @default.
• W2330504702 countsByYear W23305047022023 @default.
• W2330504702 crossrefType "journal-article" @default.
• W2330504702 hasAuthorship W2330504702A5016891775 @default.
• W2330504702 hasAuthorship W2330504702A5023828983 @default.
• W2330504702 hasAuthorship W2330504702A5025073972 @default.
• W2330504702 hasAuthorship W2330504702A5045067748 @default.
• W2330504702 hasAuthorship W2330504702A5061348764 @default.
• W2330504702 hasAuthorship W2330504702A5063628201 @default.
• W2330504702 hasAuthorship W2330504702A5075273559 @default.
• W2330504702 hasAuthorship W2330504702A5085401007 @default.
• W2330504702 hasConcept C121332964 @default.
• W2330504702 hasConcept C12554922 @default.
• W2330504702 hasConcept C126322002 @default.
• W2330504702 hasConcept C134018914 @default.
• W2330504702 hasConcept C136238340 @default.
• W2330504702 hasConcept C148898269 @default.
• W2330504702 hasConcept C166940927 @default.

• next