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- W2330509174 abstract "Recent evidence implicates a particular role for the serotonergic system in regulation of adult neurogenesis in a mouse animal model of hippocampus. Serotonin (5-HT) serves as a protector of adult neural stem cell (ANSC) growth. Lack of 5-HT caused by tryptophan-hydroxylase (TPH) depletion leads to a decrease in stem cell proliferation. Both isoforms of TPH (TPH1 and TPH2) are present in undifferentiated ANSC. So far, no reliable TPH1 and TPH2 knockout animal models are available; i.e. TPH2 KO mice are infertile. Therefore, we sought to investigate the influence of different TPH isoforms in-vitro by a selective gene-silencing approach. In addition to the lack of a suitable animal model, we sought to employ the novel technique of RNA interference in order to study TPH 1 and 2 isoforms on the particularly interesting level of adult neurogenesis." @default.
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- W2330509174 date "2005-09-01" @default.
- W2330509174 modified "2023-10-18" @default.
- W2330509174 title "Downregulation of TPH1 or rather TPH2 by stable transfection of adult neural stem cells with lentiviral vectors containing sequences for siRNAs" @default.
- W2330509174 doi "https://doi.org/10.1055/s-2005-918817" @default.
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