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• W2330547886 abstract "Purpose of review Interstitial lung disease (ILD), though a common and often a severe manifestation of many connective tissue diseases (CTD), is challenging to manage because of its variable presentation and the relative lack of guidelines to assist the clinician. In this review, we discuss the approach to diagnosis, treatment, and monitoring patients with CTD-associated ILD, with a focus on systemic sclerosis (SSc), rheumatoid arthritis (RA), and idiopathic inflammatory myopathy (IIM). Recent findings High-resolution computed tomography scan and pulmonary function testing can be reliably used to diagnose ILD and monitor progression, and often to determine its likely histologic subtype and severity. In SSc-ILD, randomized controlled trials show ILD stabilization with cyclophosphamide treatment; preliminary data from another randomized controlled trial demonstrates similar findings with mycophenolate. There are no robust clinical trials supporting specific treatments for RA-ILD or IIM-ILD, but rituximab in RA-ILD, and cyclophosphamide, mycophenolate and calcineurin inhibitors in IIM-ILD show promise. Summary Though ILD contributes substantially to morbidity and mortality in patients with CTD, there are minimal data to guide its management except in SSc-ILD." @default.
• W2330547886 created "2016-06-24" @default.
• W2330547886 creator A5053909400 @default.
• W2330547886 creator A5067859754 @default.
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• W2330547886 date "2016-05-01" @default.
• W2330547886 modified "2023-10-03" @default.
• W2330547886 title "Management of connective tissue diseases associated interstitial lung disease" @default.
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• W2330547886 doi "https://doi.org/10.1097/bor.0000000000000270" @default.
• W2330547886 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4826478" @default.
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