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- W2330574844 abstract "Conditions have been identified for the efficient Ullmann macrocyclization of phenol and imidazole nucleophiles with aryl iodides at high reaction concentrations of up to 100 mM and using 5–10 mol % loading of an inexpensive copper catalyst. A range of substitution patterns and ring sizes are tolerated, and the method has been exemplified by the synthesis of a set of druglike macrocycles." @default.
- W2330574844 created "2016-06-24" @default.
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- W2330574844 date "2012-12-06" @default.
- W2330574844 modified "2023-10-10" @default.
- W2330574844 title "Macrocyclizations for Medicinal Chemistry: Synthesis of Druglike Macrocycles by High-Concentration Ullmann Coupling" @default.
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- W2330574844 doi "https://doi.org/10.1021/jo302089f" @default.
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