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• W2330585005 abstract "You have accessJournal of UrologyKidney Cancer: Evalution/Staging III1 Apr 2014MP36-05 CELL CYCLE PROGRESSION SCORE PREDICTS METASTATIC PROGRESSION OF CLEAR CELL RENAL CELL CARCINOMA AFTER RESECTION Eric Askeland, Vincent Chehval, Ryan Askeland, Zaina Sangale, Steve Stone, Nafei Xu, Saradha Rajamani, Placede Fosso, and James Brown Eric AskelandEric Askeland More articles by this author , Vincent ChehvalVincent Chehval More articles by this author , Ryan AskelandRyan Askeland More articles by this author , Zaina SangaleZaina Sangale More articles by this author , Steve StoneSteve Stone More articles by this author , Nafei XuNafei Xu More articles by this author , Saradha RajamaniSaradha Rajamani More articles by this author , Placede FossoPlacede Fosso More articles by this author , and James BrownJames Brown More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.1069AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Clear cell renal cell carcinoma (ccRCC) is primarily treated surgically when organ confined. After resection close follow-up is required to evaluate for recurrence. Alterations in expression levels of cell cycle progression (CCP) genes have shown prognostic value in certain cancers. We sought to evaluate the prognostic value of the CCP expression profile of surgically resected ccRCC. METHODS Medical records of patients with ccRCC treated with resection were retrospectively reviewed. Patients with metastasis or lymph node involvement at the time of surgery were excluded. Those with T2a-T3b tumors were included. At least 4.5 years of follow-up without recurrence was required for the control group. Those who developed metastasis within 5 years were included in the case group. RNA was extracted from tumor specimens. Thirty-one cell cycle genes and 15 control genes were evaluated. Cell cycle genes were normalized and a CCP score was obtained. CCP score, patient sex, age at surgery, tumor stage, Fuhrman Nuclear grade (FNG), tumor size, smoking status, lymphovascular invasion (LVI), follow-up and time to metastasis were available for analysis. Univariate and multivariate logistic regression models were employed to evaluate the association of CCP and clinical parameters with metastatic progression of ccRCC. RESULTS Twenty-six cases and 38 controls were evaluated. Median time to metastasis was 1.68 years (IQR 1.06-3.69) for the case group. Median follow-up was 6.69 years (IQR 5.88-9.28) for controls. Univariate analysis revealed that LVI (OR 4.64, p=0.005), FNG (OR 4.16, p=0.0099) and CCP score (OR 2.65, p=0.0091) were the only variables which significantly predicted progression to metastasis. Multivariate logistic regression modeling using CCP and all clinical variables revealed the covariates age (p=0.026), tumor size (p=0.022) and CCP score (p=0.026) were statistical significance. Multivariate logistic regression modeling using a step-wise variable selection of age, CCP, tumor size and LVI revealed an AUC of 0.84, which decreased to 0.78 if CCP score was excluded. CONCLUSIONS The cell cycle progression score has prognostic value in predicting metastatic progression after resection of organ confined ccRCC. © 2014FiguresReferencesRelatedDetails Volume 191Issue 4SApril 2014Page: e380 Advertisement Copyright & Permissions© 2014MetricsAuthor Information Eric Askeland More articles by this author Vincent Chehval More articles by this author Ryan Askeland More articles by this author Zaina Sangale More articles by this author Steve Stone More articles by this author Nafei Xu More articles by this author Saradha Rajamani More articles by this author Placede Fosso More articles by this author James Brown More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ..." @default.
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• W2330585005 title "MP36-05 CELL CYCLE PROGRESSION SCORE PREDICTS METASTATIC PROGRESSION OF CLEAR CELL RENAL CELL CARCINOMA AFTER RESECTION" @default.
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