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- W2330588038 abstract "Background Procarcinogenic effects of the non-steroidal anti-inflammatory drug (NSAID) sulindac have been described in the mouse proximal colon. The possible role of hypoxia inducible factors (HIF) in this process is poorly understood. Aim To study histological effects of sulindac in HIF1α knockout mice. Methods Mice were bred with a specific homozygous HIF1α deletion in the colonic epithelium (n = 16) with their genotype controls that express HIF1α in the colon (n = 19). They were given a diet containing 320 ppm sulindac for 20 weeks and the dietary controls (n = 17) received mouse chow without sulindac. Biopsies from proximal to distal mouse colons were examined by light microscopy. The average number of biopsies analysed per mouse was 7.9 for the test and 8.5 for the control genotype. SPSS (Version 11) and StatXact 8 software were used for statistical analysis. Results Sulindac exposure was associated with acute and chronic inflammation. Neovascularisation, apoptosis, necrosis and fibrosis were not present. Neoplastic transformation was only seen in the mice receiving the sulindac diet (p Conclusion HIF1α may have a pro-inflammatory role in sulindac-induced carcinogenesis in the mouse proximal colon." @default.
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- W2330588038 date "2010-01-01" @default.
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- W2330588038 title "Carcinogenic effect of the NSAID sulindac in the mouse proximal colon" @default.
- W2330588038 doi "https://doi.org/10.1097/01268031-201042001-00126" @default.
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