Matches in SemOpenAlex for { <https://semopenalex.org/work/W2330651138> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2330651138 endingPage "A471" @default.
- W2330651138 startingPage "A471.1" @default.
- W2330651138 abstract "<h3>Background</h3> Diffuse alveolar hemorrhage (DAH) is a rare life-threatening complication in systemic lupus erythematosus (SLE). It is associated with a high mortality rate. Pathogenesis of DAH in patients with SLE includes disease activity; however, infection was demonstrated in more than 50% in other case series. <h3>Objectives</h3> To evaluate subgroups in a large retrospective cohort of SLE patients with DAH. <h3>Methods</h3> This retrospective cohort included 57 patients with SLE and DAH from 8 hospitals. We evaluated clinical, laboratory and treatment data. All patients met the American College of Rheumatology classification criteria for SLE. DAH was defined according to the presence of sudden drop of hemoglobin of at least 1.5 g/dL without other sources of bleeding, new infiltrates on chest radiograph and at least one of the following pulmonary symptoms: hemoptysis, dyspnea, or tachycardia. Non-parametric statistics were performed; categorical variables were compared with X<sup>2</sup> or exact Fisher-test. <h3>Results</h3> We included 57 patients with DAH and SLE, 49 (86%) were women, 14 (24.6%) children, and 24 (42.1%) died. Twenty two patients (38.6%) were diagnosed with infection (8 invasive fungal infections, 21 bacterial infections, 7 patients had mixed infections). Factors associated with mortality were: high disease activity (relative risk (RR)=2.1, confidence interval (CI): 1.1-4.1, p=0.0239), glomerular filtration rate less than 60 ml/min/1.72 m<sup>2</sup> (RR: 2.5, CI: 1.2-5.1, p=0.0052), mechanical ventilation (RR: 7.5, CI: 1.1-50.5, p-value= 0.002), infections (1.9, CI: 1.03- 3.5, p=0.04) and specifically fungal infections (RR: 2.0, CI: 1.2-3.5, p= 0.04). There were no differences in mortality rates between children and adults. Table 1 shows factors associated with infection, and that SLE treatment naïve as a “protective” factor. <h3>Conclusions</h3> DAH in SLE patients is frequently associated with infection; our series describes a subgroup analysis of this rare manifestation of SLE. Factors associated with infection can indicate therapeutic choice for the rheumatologists in SLE patients with DAH. <b>Disclosure of Interest</b>: None Declared" @default.
- W2330651138 created "2016-06-24" @default.
- W2330651138 creator A5005890361 @default.
- W2330651138 creator A5006303399 @default.
- W2330651138 creator A5017498407 @default.
- W2330651138 creator A5023638186 @default.
- W2330651138 creator A5024041744 @default.
- W2330651138 creator A5031067921 @default.
- W2330651138 creator A5036745764 @default.
- W2330651138 creator A5043947619 @default.
- W2330651138 creator A5045118635 @default.
- W2330651138 creator A5052926775 @default.
- W2330651138 creator A5053247380 @default.
- W2330651138 creator A5071207169 @default.
- W2330651138 creator A5082235231 @default.
- W2330651138 creator A5086129063 @default.
- W2330651138 date "2013-06-01" @default.
- W2330651138 modified "2023-09-26" @default.
- W2330651138 title "FRI0286 Diffuse alveolar hemorrhage in patients with systemic lupus erythematosus. a subgroup analysis." @default.
- W2330651138 doi "https://doi.org/10.1136/annrheumdis-2013-eular.1413" @default.
- W2330651138 hasPublicationYear "2013" @default.
- W2330651138 type Work @default.
- W2330651138 sameAs 2330651138 @default.
- W2330651138 citedByCount "0" @default.
- W2330651138 crossrefType "journal-article" @default.
- W2330651138 hasAuthorship W2330651138A5005890361 @default.
- W2330651138 hasAuthorship W2330651138A5006303399 @default.
- W2330651138 hasAuthorship W2330651138A5017498407 @default.
- W2330651138 hasAuthorship W2330651138A5023638186 @default.
- W2330651138 hasAuthorship W2330651138A5024041744 @default.
- W2330651138 hasAuthorship W2330651138A5031067921 @default.
- W2330651138 hasAuthorship W2330651138A5036745764 @default.
- W2330651138 hasAuthorship W2330651138A5043947619 @default.
- W2330651138 hasAuthorship W2330651138A5045118635 @default.
- W2330651138 hasAuthorship W2330651138A5052926775 @default.
- W2330651138 hasAuthorship W2330651138A5053247380 @default.
- W2330651138 hasAuthorship W2330651138A5071207169 @default.
- W2330651138 hasAuthorship W2330651138A5082235231 @default.
- W2330651138 hasAuthorship W2330651138A5086129063 @default.
- W2330651138 hasConcept C126322002 @default.
- W2330651138 hasConcept C159654299 @default.
- W2330651138 hasConcept C167135981 @default.
- W2330651138 hasConcept C198451711 @default.
- W2330651138 hasConcept C203014093 @default.
- W2330651138 hasConcept C2775915377 @default.
- W2330651138 hasConcept C2776912625 @default.
- W2330651138 hasConcept C2779134260 @default.
- W2330651138 hasConcept C2910574342 @default.
- W2330651138 hasConcept C71924100 @default.
- W2330651138 hasConcept C72563966 @default.
- W2330651138 hasConcept C90924648 @default.
- W2330651138 hasConceptScore W2330651138C126322002 @default.
- W2330651138 hasConceptScore W2330651138C159654299 @default.
- W2330651138 hasConceptScore W2330651138C167135981 @default.
- W2330651138 hasConceptScore W2330651138C198451711 @default.
- W2330651138 hasConceptScore W2330651138C203014093 @default.
- W2330651138 hasConceptScore W2330651138C2775915377 @default.
- W2330651138 hasConceptScore W2330651138C2776912625 @default.
- W2330651138 hasConceptScore W2330651138C2779134260 @default.
- W2330651138 hasConceptScore W2330651138C2910574342 @default.
- W2330651138 hasConceptScore W2330651138C71924100 @default.
- W2330651138 hasConceptScore W2330651138C72563966 @default.
- W2330651138 hasConceptScore W2330651138C90924648 @default.
- W2330651138 hasIssue "Suppl 3" @default.
- W2330651138 hasLocation W23306511381 @default.
- W2330651138 hasOpenAccess W2330651138 @default.
- W2330651138 hasPrimaryLocation W23306511381 @default.
- W2330651138 hasRelatedWork W1997186711 @default.
- W2330651138 hasRelatedWork W2026355082 @default.
- W2330651138 hasRelatedWork W2036917673 @default.
- W2330651138 hasRelatedWork W2069853302 @default.
- W2330651138 hasRelatedWork W2337107962 @default.
- W2330651138 hasRelatedWork W2413282579 @default.
- W2330651138 hasRelatedWork W2418389456 @default.
- W2330651138 hasRelatedWork W2465716550 @default.
- W2330651138 hasRelatedWork W2549648420 @default.
- W2330651138 hasRelatedWork W2549697840 @default.
- W2330651138 hasRelatedWork W2582318172 @default.
- W2330651138 hasRelatedWork W2754705477 @default.
- W2330651138 hasRelatedWork W2756253024 @default.
- W2330651138 hasRelatedWork W2789473992 @default.
- W2330651138 hasRelatedWork W2908916852 @default.
- W2330651138 hasRelatedWork W2964905828 @default.
- W2330651138 hasRelatedWork W2969836816 @default.
- W2330651138 hasRelatedWork W3032992272 @default.
- W2330651138 hasRelatedWork W3123921208 @default.
- W2330651138 hasRelatedWork W3185671647 @default.
- W2330651138 hasVolume "72" @default.
- W2330651138 isParatext "false" @default.
- W2330651138 isRetracted "false" @default.
- W2330651138 magId "2330651138" @default.
- W2330651138 workType "article" @default.