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• W2330654679 abstract "Brain electrical stimulation (BES) has long been suggested as a means of controlling pathological brain activity. In epilepsy, control of a spatially localized source, the seizure focus, may normalize neuronal dynamics. Consequently, most BES research has been directed at controlling small, local, neuronal populations. At a higher level, pathological seizure activity can be viewed as a network event that may begin without a clear spatial focus or in multiple sites and spread rapidly through a distributed cortical network. In this paper, we begin to address the implications of local control in a network scenario. To do so, we explore the efficacy of local BES when deployed over a larger-scale neuronal network, for instance, using a grid of stimulating electrodes on the cortex. By introducing a mean-field model of neuronal interactions we are able to identify limitations in network controllability based on physiological constraints that suggest the need for more nuanced network control strategies." @default.
• W2330654679 created "2016-06-24" @default.
• W2330654679 creator A5030321614 @default.
• W2330654679 creator A5057893339 @default.
• W2330654679 creator A5058048101 @default.
• W2330654679 date "2012-08-21" @default.
• W2330654679 modified "2023-10-02" @default.
• W2330654679 title "Distributed control in a mean-field cortical network model: Implications for seizure suppression" @default.
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• W2330654679 doi "https://doi.org/10.1103/physreve.86.021920" @default.
• W2330654679 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23005798" @default.
• W2330654679 hasPublicationYear "2012" @default.
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