FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2330655568> ?p ?o ?g. }

• W2330655568 abstract "Introduction Patients undergoing oesophagectomy have ~25% risk of developing post-operative Acute Lung Injury (ALI). A recent meta-analysis showed that smoking cessation prior to an operation reduces the risk of respiratory complications [1]. We hypothesised that current smokers would have an increased risk of ALI post-oesophagectomy compared with former smokers. Methods We analysed data from 14 current smokers and 37 former smokers recruited to the translational sub-study of the BALTI prevention trial. Extravascular Lung Water Index (EVLWI) and Pulmonary Vascular Permeability Index (PVPI) were measured using PICCO. Plasma and Bronchoalveolar lavage fluid (BALF) cytokine levels were measured by ELISA. Results Current smokers were significantly younger and had a lower BMI than former smokers. Current smokers were more likely to develop post-operative ALI which required ventilation but there was no difference in the rate of respiratory infection. PVPI was significantly higher immediately post op and on day 1 post op and EVLWI was significantly higher on day 1 post op in current smokers (see table). Plasma levels of FAS ligand were significantly lower in current smokers pre-op, post-op and on day 1 post-op. Pre-op plasma levels of sICAM1 were significantly higher in current smokers but there was no difference in post-op levels. Plasma levels of IL-17 were lower pre-op, post-op and on day 1, although only the post-op difference reached significance. In BAL, levels of VEGF were significantly lower and levels of IL1ra and TNFR1 were significantly higher in current smokers (see table). Conclusion Current smokers have a higher risk of Acute Lung Injury following oesophagectomy than former smokers. This finding is supported by higher post-operative levels of extravascular lung water and pulmonary vascular permeability and differences in both plasma and BAL cytokines in current smokers. Our data highlights the importance of encouraging patients to stop smoking prior to major surgery as well as the need to control for smoking history in trials aiming to ameliorate lung injury in this patient group. References Wong, J. et al. Short-term preoperative smoking cessation and postoperative complications: a systematic review and meta-analysis. Can J Anaesth, 2012. 59(3): 268–79" @default.
• W2330655568 created "2016-06-24" @default.
• W2330655568 creator A5013778443 @default.
• W2330655568 creator A5041103166 @default.
• W2330655568 creator A5043836434 @default.
• W2330655568 creator A5053516925 @default.
• W2330655568 creator A5058487601 @default.
• W2330655568 creator A5090181280 @default.
• W2330655568 date "2013-11-14" @default.
• W2330655568 modified "2023-09-26" @default.
• W2330655568 title "P147 Current smokers face increased risk of Acute Lung Injury post oesophagectomy compared to former smokers- implications for therapy and trial design?: Abstract P147 Table 1." @default.
• W2330655568 cites W2178422374 @default.
• W2330655568 doi "https://doi.org/10.1136/thoraxjnl-2013-204457.297" @default.
• W2330655568 hasPublicationYear "2013" @default.
• W2330655568 type Work @default.
• W2330655568 sameAs 2330655568 @default.
• W2330655568 citedByCount "0" @default.
• W2330655568 crossrefType "journal-article" @default.
• W2330655568 hasAuthorship W2330655568A5013778443 @default.
• W2330655568 hasAuthorship W2330655568A5041103166 @default.
• W2330655568 hasAuthorship W2330655568A5043836434 @default.
• W2330655568 hasAuthorship W2330655568A5053516925 @default.
• W2330655568 hasAuthorship W2330655568A5058487601 @default.
• W2330655568 hasAuthorship W2330655568A5090181280 @default.
• W2330655568 hasBestOaLocation W23306555681 @default.
• W2330655568 hasConcept C126322002 @default.
• W2330655568 hasConcept C141071460 @default.
• W2330655568 hasConcept C2777714996 @default.
• W2330655568 hasConcept C2777961210 @default.
• W2330655568 hasConcept C42219234 @default.
• W2330655568 hasConcept C534529494 @default.
• W2330655568 hasConcept C71924100 @default.
• W2330655568 hasConcept C90924648 @default.
• W2330655568 hasConceptScore W2330655568C126322002 @default.
• W2330655568 hasConceptScore W2330655568C141071460 @default.
• W2330655568 hasConceptScore W2330655568C2777714996 @default.
• W2330655568 hasConceptScore W2330655568C2777961210 @default.
• W2330655568 hasConceptScore W2330655568C42219234 @default.
• W2330655568 hasConceptScore W2330655568C534529494 @default.
• W2330655568 hasConceptScore W2330655568C71924100 @default.
• W2330655568 hasConceptScore W2330655568C90924648 @default.
• W2330655568 hasLocation W23306555681 @default.
• W2330655568 hasLocation W23306555682 @default.
• W2330655568 hasOpenAccess W2330655568 @default.
• W2330655568 hasPrimaryLocation W23306555681 @default.
• W2330655568 hasRelatedWork W1565795818 @default.
• W2330655568 hasRelatedWork W1574851241 @default.
• W2330655568 hasRelatedWork W1845105241 @default.
• W2330655568 hasRelatedWork W2032120081 @default.
• W2330655568 hasRelatedWork W2044930207 @default.
• W2330655568 hasRelatedWork W2083583305 @default.
• W2330655568 hasRelatedWork W2106071193 @default.
• W2330655568 hasRelatedWork W2113550434 @default.
• W2330655568 hasRelatedWork W2301909642 @default.
• W2330655568 hasRelatedWork W2320773712 @default.
• W2330655568 hasRelatedWork W2349043145 @default.
• W2330655568 hasRelatedWork W2351481055 @default.
• W2330655568 hasRelatedWork W2408179718 @default.
• W2330655568 hasRelatedWork W2587883742 @default.
• W2330655568 hasRelatedWork W2905939468 @default.
• W2330655568 hasRelatedWork W2919124580 @default.
• W2330655568 hasRelatedWork W2923041576 @default.
• W2330655568 hasRelatedWork W3030203165 @default.
• W2330655568 hasRelatedWork W3189138257 @default.
• W2330655568 hasRelatedWork W3190531857 @default.
• W2330655568 isParatext "false" @default.
• W2330655568 isRetracted "false" @default.
• W2330655568 magId "2330655568" @default.
• W2330655568 workType "article" @default.