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- W2330658439 abstract "Background: Classical histopathological groups of breast cancer have recently been less studied in relation to etiological factors than the new more molecular oriented taxonomy such as luminal A,B, Her2-neu and basal type of breast cancer. In the present investigation we have related histopathology to breast cancer risk factors to shed light on the possibility that the classical taxonomy may have a biological meaning presently not fully recognized.Material and methods:In 1677 consecutive breast cancer patients the following risk factors were related to histopathology; parity, HRT use, breast cancer screening, vertical inheritance of breast cancer (possibly dominant), horizontal inheritance of breast cancer (possibly recessive), and germline mutation carrier status (BRCA1, BRCA2, CDKN2A, p53). Patients with mixed tumor types were excluded. All analyses were age adjusted and factors were simultaneously adjusted for.Results: A germline mutation was present in 1.5% of the cases. A relationship between medullary tumors and BRCA1 mutations was seen. Germline mutation carriers were in further analysis excluded. Among remaining cases a vertical family history was present in 23% and a horizontal one in 5% of the cases. A horizontal family history was significantly associated with tubular tumor type (OR=3.9, 1.4-10.4) and age, and non-significantly associated with tumor progesterone receptor content (OR=1.7, 0.8-4.0), and lobular tumor type (OR=1.4, 0.6-3.2). A vertical family history was significantly related to tumor multifocality (OR=2.3, 1.5-3.5), tumor bilaterality (OR=2.1, 1.4-3.0) and screening detection (OR=1.5, 1.1-2.1), while age and a tubuloductal tumor type (OR=0.5, 0.3-0.9) were significantly negatively related. Patients with ductal and mucinous tumors had significantly fewer children (OR=0.9, 0.8-0.99) and (OR=0.6, 0.4-0.8) respectively, while patients with comedocancer had significantly more children (OR=1.2, 1.1-1.4) .HRT use increased non significantly the risk for lobular breast cancer, while significantly being related to mixed lobular cases.Conclusion.These results demonstrate that classical histopathological groups are related to breast cancer risk factors and indeed may have a biological relationship to etiological factors.Especially factors related to parity, HRT use and family history seem to relate to different histopathological groups. Molecular signatures as well as classical histopathology should be used in future risk factor studies. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 6065." @default.
- W2330658439 created "2016-06-24" @default.
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- W2330658439 date "2009-12-15" @default.
- W2330658439 modified "2023-09-27" @default.
- W2330658439 title "Risk Factors of Breast Cancer in Relation to Classical Histopathology." @default.
- W2330658439 doi "https://doi.org/10.1158/0008-5472.sabcs-09-6065" @default.
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