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- W2330685771 abstract "The genus Onosma (Boraginaceae) is represented by 87 species in Turkey (1). The roots of some Onosma species are used for wound healing, burns, hemorrhoids, gastric ulcer, and tonsillitis in Turkey (2,3). The roots of some Onosma species are known to be rich in napthoquinones. In our previous study, some naphthoquinones namely deoxyshikonin, acetyl shikonin and β,β-dimethylacrylshikonin were purified by various chromatographic techniques from n-hexane-dichloromethane (1:1) extracts of the roots of Onosma species studied (4). In the present research, as a part of our studies on Onosma species, we aimed to investigate cholinesterase and tyrosinase inhibitory potential of the n-hexane-dichloromethane (1:1) extracts of the roots of O. nigricaule (endemic), O. obtusifolium (endemic), O. tauricum and O. armeniacum. Napthoquinones isolated were tested against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) as well as tyrosinase (TYRO) at 100 mg/mL using microtiter plate assays by ELISA. Since oxidative damage is associated with neurodegenerative diseases, the extracts were tested for their antioxidant effect by five in vitro assays including 2,2-diphenyl-1-picrylhydrazyl, N,N-dimethyl-p-phenylendiamine, and nitric oxide radical quenching effect, metal-chelation effect, and ferric-, and phosphomolibdenum-reducing antioxidant power. According to the results, only the extract of O. nigricaule exerted a notable inhibition against AChE, against BChE, and the highest tyrosinase inhibitory activity as well. Acetyl shikonin and β,β-dimethylacrylshikonin also possessed moderate BChE inhibition and phosphomolibdenum-reducing antioxidant power." @default.
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- W2330685771 date "2013-08-21" @default.
- W2330685771 modified "2023-09-26" @default.
- W2330685771 title "Cholinesterase and tyrosinase inhibition studies and antioxidant activities of four Onosma species from Turkey" @default.
- W2330685771 doi "https://doi.org/10.1055/s-0033-1352432" @default.
- W2330685771 hasPublicationYear "2013" @default.
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