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- W2330687170 abstract "In the present study, the possibility of an interaction between prescription drugs and over-the-counter (OTC) drugs was investigated by monitoring plasma drug concentrations in rats. When a levodopa preparation (Madopar®) indicated for patients with Parkinson's disease was orally administered with Saclon®, an OTC drug for upset stomach, the AUC and Cmax for levodopa were significantly lowered and Tmax was significantly prolonged. These results indicate that there may be an interaction between a levodopa preparation and Saclon® when administered together, which leads to a reduction in the bioavailability of levodopa. Similar results were obtained when the levodopa preparation and the main ingredient of Saclon®, a copper chlorophyllin salt, were concomitantly administered. Taken together, our results indicate that the copper chlorophyllin salt in Saclon® may interact with levodopa preparations. The possibility of such an interaction should therefore be kept in mind during levodopa therapy for patients with Parkinson's disease." @default.
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- W2330687170 date "2006-01-01" @default.
- W2330687170 modified "2023-09-24" @default.
- W2330687170 title "Possibility of Interactions between Prescription Drugs and OTC Drugs-Interaction between Levodopa Preparation and Saclon, an OTC Drug for Upset Stomach-" @default.
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- W2330687170 doi "https://doi.org/10.5649/jjphcs.32.73" @default.
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