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- W2330708657 endingPage "2715" @default.
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- W2330708657 abstract "A library of 29 organoosmium compounds has been built up with known and novel cyclometalated compounds obtained with C–N, N∧C∧N, and C∧N∧N ligands. All compounds have been tested for their in vitro cytotoxic properties against A172, a tumor cell line derived from a human glioblastoma, this affording a contrasted picture of the activities of the compounds gathered in this study. Some compounds displayed good to excellent activities, some of them showing IC50 in the nanomolar range. The level of activity was tentatively correlated to several physicochemical properties of the compounds such as their E01/2(OsIII/II) redox potential and their lipophilicity (log Po/w). A parallel with related ruthenium derivatives was tentatively proposed." @default.
- W2330708657 created "2016-06-24" @default.
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- W2330708657 date "2013-02-21" @default.
- W2330708657 modified "2023-10-10" @default.
- W2330708657 title "Cancer Cell Cytotoxicity of Cyclometalated Compounds Obtained with Osmium(II) Complexes" @default.
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- W2330708657 doi "https://doi.org/10.1021/ic302779q" @default.
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