FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2330709747> ?p ?o ?g. }

• W2330709747 endingPage "351" @default.
• W2330709747 startingPage "343" @default.
• W2330709747 abstract "The life cycle of human immunodeficiency virus type 1 (HIV-1) is critically dependent on the transregulatory proteins Tat and Rev. Tat increases the production of HIV-specific mRNAs by direct binding to the transactivation response (TAR) element located at the 5' end of all HIV transcripts. In contrast, Rev uses a complex RNA stem loop structure, the Rev response element (RRE), which is found in full-length and singly spliced HIV transcripts. Rev is required for the cytoplasmic expression of full-length mRNAs encoding Gag, Pol, and Env structural proteins. The complex intracellular interactions between Tat, Rev, host cell factors, and their respective RNA response elements should be susceptible to interdiction by genetic therapies designed to introduce and express novel genetic information. We show that the expression of antisense RREs inhibited the cytoplasmic expression of RRE containing HIV-1 transcripts. HIV-based retroviral vectors containing either the antisense (-) or sense (+) RREs inhibited HIV replication in transient transfections. The production of full-length HIV mRNA was also decreased significantly by the expression of RREs in either orientation. Interestingly, there was a paradoxic increase in HIV p24 gag production at low levels of inhibitor; this effect may have been the result of encapsidation of RRE-containing HIV-based retroviral vectors. The data suggest that the introduction and inducible expression of RRE-containing, HIV-based retroviral vectors may have therapeutic value in HIV infection." @default.
• W2330709747 created "2016-06-24" @default.
• W2330709747 creator A5001108158 @default.
• W2330709747 creator A5030789303 @default.
• W2330709747 creator A5075675860 @default.
• W2330709747 creator A5077195646 @default.
• W2330709747 creator A5082702766 @default.
• W2330709747 creator A5085225085 @default.
• W2330709747 date "1996-08-01" @default.
• W2330709747 modified "2023-10-16" @default.
• W2330709747 title "Inhibition of HIV Replication by Sense and Antisense Rev Response Elements in HIV-Based Retroviral Vectors" @default.
• W2330709747 cites W1414798254 @default.
• W2330709747 cites W1489706303 @default.
• W2330709747 cites W1490558618 @default.
• W2330709747 cites W1514840588 @default.
• W2330709747 cites W1545240550 @default.
• W2330709747 cites W1547451054 @default.
• W2330709747 cites W1551381216 @default.
• W2330709747 cites W1572649493 @default.
• W2330709747 cites W1588071325 @default.
• W2330709747 cites W1766215719 @default.
• W2330709747 cites W1811305969 @default.
• W2330709747 cites W1876741505 @default.
• W2330709747 cites W1893117590 @default.
• W2330709747 cites W1925157233 @default.
• W2330709747 cites W1939899968 @default.
• W2330709747 cites W1942164998 @default.
• W2330709747 cites W1964916693 @default.
• W2330709747 cites W1966425882 @default.
• W2330709747 cites W1981247709 @default.
• W2330709747 cites W1981421762 @default.
• W2330709747 cites W1981457569 @default.
• W2330709747 cites W1981578463 @default.
• W2330709747 cites W1985861003 @default.
• W2330709747 cites W2015625581 @default.
• W2330709747 cites W2016328587 @default.
• W2330709747 cites W2019143192 @default.
• W2330709747 cites W2021637244 @default.
• W2330709747 cites W2026102468 @default.
• W2330709747 cites W2029467097 @default.
• W2330709747 cites W2030017358 @default.
• W2330709747 cites W2030588812 @default.
• W2330709747 cites W2052543680 @default.
• W2330709747 cites W2053037116 @default.
• W2330709747 cites W2064039566 @default.
• W2330709747 cites W2065978009 @default.
• W2330709747 cites W2067072259 @default.
• W2330709747 cites W2077430714 @default.
• W2330709747 cites W2079134008 @default.
• W2330709747 cites W2083324135 @default.
• W2330709747 cites W2084208256 @default.
• W2330709747 cites W2084627994 @default.
• W2330709747 cites W2092047133 @default.
• W2330709747 cites W2094650831 @default.
• W2330709747 cites W2105144789 @default.
• W2330709747 cites W2105192976 @default.
• W2330709747 cites W2117460367 @default.
• W2330709747 cites W2118669004 @default.
• W2330709747 cites W2121430971 @default.
• W2330709747 cites W2123425704 @default.
• W2330709747 cites W2128398347 @default.
• W2330709747 cites W2137908074 @default.
• W2330709747 cites W2138851210 @default.
• W2330709747 cites W2146702776 @default.
• W2330709747 cites W2149134545 @default.
• W2330709747 cites W4211088784 @default.
• W2330709747 doi "https://doi.org/10.1097/00042560-199608010-00003" @default.
• W2330709747 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8673542" @default.
• W2330709747 hasPublicationYear "1996" @default.
• W2330709747 type Work @default.
• W2330709747 sameAs 2330709747 @default.
• W2330709747 citedByCount "23" @default.
• W2330709747 countsByYear W23307097472012 @default.
• W2330709747 crossrefType "journal-article" @default.
• W2330709747 hasAuthorship W2330709747A5001108158 @default.
• W2330709747 hasAuthorship W2330709747A5030789303 @default.
• W2330709747 hasAuthorship W2330709747A5075675860 @default.
• W2330709747 hasAuthorship W2330709747A5077195646 @default.
• W2330709747 hasAuthorship W2330709747A5082702766 @default.
• W2330709747 hasAuthorship W2330709747A5085225085 @default.
• W2330709747 hasBestOaLocation W23307097471 @default.
• W2330709747 hasConcept C104317684 @default.
• W2330709747 hasConcept C1292079 @default.
• W2330709747 hasConcept C140704245 @default.
• W2330709747 hasConcept C143141573 @default.
• W2330709747 hasConcept C147789679 @default.
• W2330709747 hasConcept C150194340 @default.
• W2330709747 hasConcept C159047783 @default.
• W2330709747 hasConcept C185592680 @default.
• W2330709747 hasConcept C199491388 @default.
• W2330709747 hasConcept C202416437 @default.
• W2330709747 hasConcept C2522874641 @default.
• W2330709747 hasConcept C2910020833 @default.
• W2330709747 hasConcept C3013748606 @default.
• W2330709747 hasConcept C54355233 @default.
• W2330709747 hasConcept C67705224 @default.
• W2330709747 hasConcept C86803240 @default.
• W2330709747 hasConcept C95444343 @default.

• next