Matches in SemOpenAlex for { <https://semopenalex.org/work/W2330712443> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2330712443 endingPage "3531" @default.
- W2330712443 startingPage "3525" @default.
- W2330712443 abstract "The protein encoded by the murine double minute 2 (Mdm2) gene inactivates the function of the tumor suppressor p53. The targeted expression of the mdm2 transgene (BLGmdm2) to the mammary epithelium disrupts the cell cycle, causing multiple rounds of DNA synthesis without proper cell division and consequently poor mammary gland development. These phenotypes in the mammary epithelia of the transgenic mice are not dependent on either p53 or the transcription factor E2F1, as mice null for these genes carrying the BLGmdm2 transgene exhibit similar defects to mice carrying the BLGmdm2 transgene alone. p19ARF, an alternative splice product of the INK4a/ARF locus, has been shown to interact directly with MDM2. Therefore, BLGmdm2 transgenic mice null for p19ARF were created to gain insight into the mechanism by which mdm2 overexpression disrupts the cell cycle. The BLGmdm2 phenotype in the absence of p19ARF was worse than BLGmdm2 mice and visible as early as day 15 of pregnancy. By day 5 of lactation the phenotype was very pronounced. Histological analysis of the mammary gland showed a decrease in ductal branching, smaller and fewer lobuloalveolar structures, and a decrease in luminal secretions. Multinucleated and enlarged cells were present due to continued replication in the absence of cytokinesis. Thus, the absence of p19ARF in this in vivo system enhanced the defect caused by mdm2 overexpression." @default.
- W2330712443 created "2016-06-24" @default.
- W2330712443 creator A5011897647 @default.
- W2330712443 creator A5076622040 @default.
- W2330712443 date "2002-05-16" @default.
- W2330712443 modified "2023-10-17" @default.
- W2330712443 title "Loss of p19ARF enhances the defects of Mdm2 overexpression in the mammary gland" @default.
- W2330712443 cites W1969044026 @default.
- W2330712443 cites W1973886069 @default.
- W2330712443 cites W1975390889 @default.
- W2330712443 cites W1983751803 @default.
- W2330712443 cites W1986512406 @default.
- W2330712443 cites W1993864973 @default.
- W2330712443 cites W2001480633 @default.
- W2330712443 cites W2007249806 @default.
- W2330712443 cites W2008072603 @default.
- W2330712443 cites W2031368311 @default.
- W2330712443 cites W2032911567 @default.
- W2330712443 cites W2033889343 @default.
- W2330712443 cites W2039335985 @default.
- W2330712443 cites W2039463309 @default.
- W2330712443 cites W2046958356 @default.
- W2330712443 cites W2049085719 @default.
- W2330712443 cites W2056530510 @default.
- W2330712443 cites W2057594508 @default.
- W2330712443 cites W2069059286 @default.
- W2330712443 cites W2072472133 @default.
- W2330712443 cites W2082979850 @default.
- W2330712443 cites W2084891010 @default.
- W2330712443 cites W2091151265 @default.
- W2330712443 cites W2099907467 @default.
- W2330712443 cites W2100876151 @default.
- W2330712443 cites W2106048601 @default.
- W2330712443 cites W2138302361 @default.
- W2330712443 cites W2155710216 @default.
- W2330712443 cites W2158726042 @default.
- W2330712443 cites W2162888470 @default.
- W2330712443 cites W4248611167 @default.
- W2330712443 doi "https://doi.org/10.1038/sj.onc.1205441" @default.
- W2330712443 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12032854" @default.
- W2330712443 hasPublicationYear "2002" @default.
- W2330712443 type Work @default.
- W2330712443 sameAs 2330712443 @default.
- W2330712443 citedByCount "11" @default.
- W2330712443 countsByYear W23307124432015 @default.
- W2330712443 countsByYear W23307124432017 @default.
- W2330712443 crossrefType "journal-article" @default.
- W2330712443 hasAuthorship W2330712443A5011897647 @default.
- W2330712443 hasAuthorship W2330712443A5076622040 @default.
- W2330712443 hasBestOaLocation W23307124431 @default.
- W2330712443 hasConcept C102230213 @default.
- W2330712443 hasConcept C104317684 @default.
- W2330712443 hasConcept C141035611 @default.
- W2330712443 hasConcept C190283241 @default.
- W2330712443 hasConcept C2776192174 @default.
- W2330712443 hasConcept C2778264664 @default.
- W2330712443 hasConcept C29537977 @default.
- W2330712443 hasConcept C502942594 @default.
- W2330712443 hasConcept C54355233 @default.
- W2330712443 hasConcept C555283112 @default.
- W2330712443 hasConcept C86803240 @default.
- W2330712443 hasConcept C95444343 @default.
- W2330712443 hasConceptScore W2330712443C102230213 @default.
- W2330712443 hasConceptScore W2330712443C104317684 @default.
- W2330712443 hasConceptScore W2330712443C141035611 @default.
- W2330712443 hasConceptScore W2330712443C190283241 @default.
- W2330712443 hasConceptScore W2330712443C2776192174 @default.
- W2330712443 hasConceptScore W2330712443C2778264664 @default.
- W2330712443 hasConceptScore W2330712443C29537977 @default.
- W2330712443 hasConceptScore W2330712443C502942594 @default.
- W2330712443 hasConceptScore W2330712443C54355233 @default.
- W2330712443 hasConceptScore W2330712443C555283112 @default.
- W2330712443 hasConceptScore W2330712443C86803240 @default.
- W2330712443 hasConceptScore W2330712443C95444343 @default.
- W2330712443 hasIssue "22" @default.
- W2330712443 hasLocation W23307124431 @default.
- W2330712443 hasLocation W23307124432 @default.
- W2330712443 hasOpenAccess W2330712443 @default.
- W2330712443 hasPrimaryLocation W23307124431 @default.
- W2330712443 hasRelatedWork W1536426327 @default.
- W2330712443 hasRelatedWork W1973459962 @default.
- W2330712443 hasRelatedWork W2030084515 @default.
- W2330712443 hasRelatedWork W2064668712 @default.
- W2330712443 hasRelatedWork W2070974215 @default.
- W2330712443 hasRelatedWork W2158124286 @default.
- W2330712443 hasRelatedWork W2398991683 @default.
- W2330712443 hasRelatedWork W2407241705 @default.
- W2330712443 hasRelatedWork W2413400652 @default.
- W2330712443 hasRelatedWork W51112303 @default.
- W2330712443 hasVolume "21" @default.
- W2330712443 isParatext "false" @default.
- W2330712443 isRetracted "false" @default.
- W2330712443 magId "2330712443" @default.
- W2330712443 workType "article" @default.