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- W2330713089 abstract "Purpose.: Keratoconic corneas exhibit more mitochondrial DNA (mtDNA) damage than do normal corneas and thus mtDNA may represent a potential candidate for genetic susceptibility studies in keratoconus. To test this hypothesis we determined mitochondrial haplogroups in Saudi patients with keratoconus and healthy controls of same ethnicity. Methods.: Mitochondrial haplogrouping was performed by polymerase chain reaction–based automated Sanger sequencing in 114 patients with keratoconus and 552 healthy controls. Results.: Mitochondrial haplogroups H and R were significantly overrepresented in patients with keratoconus (28.9% vs. 8.5%, P < 0.0001 and 17.5% vs. 3.1%, P < 0.0001, respectively) as compared to healthy controls. Conclusions.: Our data suggest that individuals with mitochondrial haplogroups H and R are at increased risk to develop keratoconus. In addition, the results provide further evidence for a plausible role of mtDNA in keratoconus etiology." @default.
- W2330713089 created "2016-06-24" @default.
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- W2330713089 date "2014-05-01" @default.
- W2330713089 modified "2023-10-16" @default.
- W2330713089 title "Association of Mitochondrial Haplogroups H and R With Keratoconus in Saudi Arabian Patients" @default.
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- W2330713089 doi "https://doi.org/10.1167/iovs.14-14300" @default.
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