FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2330757984> ?p ?o ?g. }

• W2330757984 abstract "You have accessJournal of UrologyBenign Prostatic Hyperplasia: Medical & Non-surgical Therapy1 Apr 2016PD22-08 CLINICALLY MEANINGFUL IMPROVEMENTS IN LUTS/BPH SEVERITY IN MEN TREATED WITH SILODOSIN PLUS SERENOA REPENS OR SILODOSIN ALONE Luca Boeri, Paolo Capogrosso, Eugenio Ventimiglia, Giovanni La Croce, Donatella Moretti, Roberta Scano, Luca Villa, Federico Dehò, Alberto Briganti, Vincenzo Mirone, Francesco Montorsi, and Andrea Salonia Luca BoeriLuca Boeri More articles by this author , Paolo CapogrossoPaolo Capogrosso More articles by this author , Eugenio VentimigliaEugenio Ventimiglia More articles by this author , Giovanni La CroceGiovanni La Croce More articles by this author , Donatella MorettiDonatella Moretti More articles by this author , Roberta ScanoRoberta Scano More articles by this author , Luca VillaLuca Villa More articles by this author , Federico DehòFederico Dehò More articles by this author , Alberto BrigantiAlberto Briganti More articles by this author , Vincenzo MironeVincenzo Mirone More articles by this author , Francesco MontorsiFrancesco Montorsi More articles by this author , and Andrea SaloniaAndrea Salonia More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.02.1501AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The effectiveness of silodosin 8 mg once daily combined with serenoa repens 320 mg (Ser) in men with LUTS/BPH has been scantly analysed. We sought to assess the rate of and predictors of clinically meaningful improvements (MIC) in LUTSBPH in patients treated with either silodosin as a monotherapy (SIL) or silodosin plus Ser (SIL+Ser) in the real-life setting. METHODS Complete data from the last 190 patients seeking medical help for LUTS/BPH at a single academic outpatient clinic and who have been treated with either SIL or SIL+Ser were collected. All patients completed the IPSS at baseline and after a minimum of 6 months of treatment. For the specific purpose of the study, only patients with baseline IPSS >12 were considered. Two MICs were assessed: MIC1 >3 points of improvement in terms of total IPSS; and, MIC2 >25% of improvement in terms of total IPSS from the baseline. Comorbidities were scored with the Charlson Comorbidity Index (CCI). Prostate volume (PV) and Qmax were collected at baseline. Descriptive statistics and logistic regression models were applied to assess rates of and predictors of MIC. RESULTS Of 190 patients, data from 97 (51.1%) SIL and 93 (48.9%) SIL+Ser patients were analysed, with a men (SD) follow-up of 10.7 (4.1) months. Overall, baseline total PSA, PV and Qmax were 2.8 (2.9) ng/mL, 54.6 (29.4) mL and 12.6 (6.6) mL/sec, respectively. Baseline IPSS and QoL scores were 17.6 (5.5) and 3.35 (1.5), respectively. No differences in terms of age, CCI, BMI, baseline IPSS, PV and Qmax were observed between groups. At mean follow-up assessment total IPSS score significantly decreased after both SIL (pre vs. post: 16.9 vs 14.5; p<0.001) and SIL+Ser (18.25 vs. 11.8; p<0.001). However, total IPSS was lower in patients treated with SIL+Ser than in those treated with SIL [14.5 (5.5) vs 11.8 (6.0), p=0.002]. A greater proportion of SIL patients still had IPSS scores suggestive for severe LUTS than SIL+Ser men (18.6% vs. 11.8%; p=0.01). MIC1 (59.1% vs. 40.9%; p<0.001) and MIC2 (64.0% vs. 36.0%; p<0.001) were achieved in a greater proportion of SIL+Ser patients compared to SIL patients. At MVA, age (OR 0.95; p=0.04) and baseline IPSS (OR 1.1; p=0.005) achieved independent predictor status for MIC1 after accounting for CCI, type of treatment, PV and Qmax. Similarly, age (OR 0.95; p=0.03), baseline IPSS (OR 1.1; p=0.04) and SIL+Ser treatment (OR 2.9; p=0.01) were independent predictors of MIC2. CONCLUSIONS The combination of SIL and Ser led to MIC in approximately 60% of LUTS/BPH patients. Younger age and baseline IPSS are independent predictors for significant MIC in terms of LUTS severity. © 2016FiguresReferencesRelatedDetails Volume 195Issue 4SApril 2016Page: e464 Advertisement Copyright & Permissions© 2016MetricsAuthor Information Luca Boeri More articles by this author Paolo Capogrosso More articles by this author Eugenio Ventimiglia More articles by this author Giovanni La Croce More articles by this author Donatella Moretti More articles by this author Roberta Scano More articles by this author Luca Villa More articles by this author Federico Dehò More articles by this author Alberto Briganti More articles by this author Vincenzo Mirone More articles by this author Francesco Montorsi More articles by this author Andrea Salonia More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ..." @default.
• W2330757984 created "2016-06-24" @default.
• W2330757984 creator A5021077905 @default.
• W2330757984 creator A5029050000 @default.
• W2330757984 creator A5031550729 @default.
• W2330757984 creator A5039363062 @default.
• W2330757984 creator A5042911985 @default.
• W2330757984 creator A5056920953 @default.
• W2330757984 creator A5057942422 @default.
• W2330757984 creator A5061623935 @default.
• W2330757984 creator A5072937184 @default.
• W2330757984 creator A5075830981 @default.
• W2330757984 creator A5076870899 @default.
• W2330757984 creator A5080848964 @default.
• W2330757984 date "2016-04-01" @default.
• W2330757984 modified "2023-09-24" @default.
• W2330757984 title "PD22-08 CLINICALLY MEANINGFUL IMPROVEMENTS IN LUTS/BPH SEVERITY IN MEN TREATED WITH SILODOSIN PLUS SERENOA REPENS OR SILODOSIN ALONE" @default.
• W2330757984 doi "https://doi.org/10.1016/j.juro.2016.02.1501" @default.
• W2330757984 hasPublicationYear "2016" @default.
• W2330757984 type Work @default.
• W2330757984 sameAs 2330757984 @default.
• W2330757984 citedByCount "0" @default.
• W2330757984 crossrefType "journal-article" @default.
• W2330757984 hasAuthorship W2330757984A5021077905 @default.
• W2330757984 hasAuthorship W2330757984A5029050000 @default.
• W2330757984 hasAuthorship W2330757984A5031550729 @default.
• W2330757984 hasAuthorship W2330757984A5039363062 @default.
• W2330757984 hasAuthorship W2330757984A5042911985 @default.
• W2330757984 hasAuthorship W2330757984A5056920953 @default.
• W2330757984 hasAuthorship W2330757984A5057942422 @default.
• W2330757984 hasAuthorship W2330757984A5061623935 @default.
• W2330757984 hasAuthorship W2330757984A5072937184 @default.
• W2330757984 hasAuthorship W2330757984A5075830981 @default.
• W2330757984 hasAuthorship W2330757984A5076870899 @default.
• W2330757984 hasAuthorship W2330757984A5080848964 @default.
• W2330757984 hasBestOaLocation W23307579841 @default.
• W2330757984 hasConcept C121608353 @default.
• W2330757984 hasConcept C126322002 @default.
• W2330757984 hasConcept C126894567 @default.
• W2330757984 hasConcept C2776235491 @default.
• W2330757984 hasConcept C2779161064 @default.
• W2330757984 hasConcept C2779478474 @default.
• W2330757984 hasConcept C29456083 @default.
• W2330757984 hasConcept C71924100 @default.
• W2330757984 hasConceptScore W2330757984C121608353 @default.
• W2330757984 hasConceptScore W2330757984C126322002 @default.
• W2330757984 hasConceptScore W2330757984C126894567 @default.
• W2330757984 hasConceptScore W2330757984C2776235491 @default.
• W2330757984 hasConceptScore W2330757984C2779161064 @default.
• W2330757984 hasConceptScore W2330757984C2779478474 @default.
• W2330757984 hasConceptScore W2330757984C29456083 @default.
• W2330757984 hasConceptScore W2330757984C71924100 @default.
• W2330757984 hasIssue "4S" @default.
• W2330757984 hasLocation W23307579841 @default.
• W2330757984 hasOpenAccess W2330757984 @default.
• W2330757984 hasPrimaryLocation W23307579841 @default.
• W2330757984 hasRelatedWork W1973801649 @default.
• W2330757984 hasRelatedWork W2019430383 @default.
• W2330757984 hasRelatedWork W2028992565 @default.
• W2330757984 hasRelatedWork W2087111859 @default.
• W2330757984 hasRelatedWork W2606375534 @default.
• W2330757984 hasRelatedWork W2811320370 @default.
• W2330757984 hasRelatedWork W2926120015 @default.
• W2330757984 hasRelatedWork W2982544720 @default.
• W2330757984 hasRelatedWork W3015122522 @default.
• W2330757984 hasRelatedWork W4283729733 @default.
• W2330757984 hasVolume "195" @default.
• W2330757984 isParatext "false" @default.
• W2330757984 isRetracted "false" @default.
• W2330757984 magId "2330757984" @default.
• W2330757984 workType "article" @default.