Matches in SemOpenAlex for { <https://semopenalex.org/work/W2330763603> ?p ?o ?g. }
- W2330763603 endingPage "1523" @default.
- W2330763603 startingPage "1511" @default.
- W2330763603 abstract "Tiam1 is one of the most extensively analyzed activators of the small GTPase Rac. However, fundamental aspects of its regulation are poorly understood. Here we demonstrate that Tiam1 is functionally suppressed by internal interactions and that the PAR complex participates in its full activation. The N-terminal region of Tiam1 binds to the protein-binding and catalytic domains to inhibit its localization and activation. Atypical PKCs phosphorylate Tiam1 to relieve its intramolecular interactions, and the subsequent stabilization of its interaction with PAR3 allows it to exert localized activity. By analyzing Tiam1 regulation by PAR3-aPKC within the context of PDGF signaling, we also show that PAR3 directly binds PDGF receptor β. Thus we provide the first evidence for the negative regulation of Tiam1 by internal interactions, elucidate the nature of Tiam1 regulation by the PAR complex, and reveal a novel role for the PAR complex in PDGF signaling." @default.
- W2330763603 created "2016-06-24" @default.
- W2330763603 creator A5001426883 @default.
- W2330763603 creator A5012487815 @default.
- W2330763603 creator A5025062231 @default.
- W2330763603 creator A5025713245 @default.
- W2330763603 creator A5036826295 @default.
- W2330763603 creator A5086804597 @default.
- W2330763603 creator A5087136130 @default.
- W2330763603 date "2016-05-01" @default.
- W2330763603 modified "2023-10-16" @default.
- W2330763603 title "PAR3-aPKC regulates Tiam1 by modulating suppressive internal interactions" @default.
- W2330763603 cites W1522344314 @default.
- W2330763603 cites W1868638618 @default.
- W2330763603 cites W1964118513 @default.
- W2330763603 cites W1970338125 @default.
- W2330763603 cites W1972747383 @default.
- W2330763603 cites W1975357249 @default.
- W2330763603 cites W1977679299 @default.
- W2330763603 cites W1979435019 @default.
- W2330763603 cites W1983833215 @default.
- W2330763603 cites W1989143807 @default.
- W2330763603 cites W1994375558 @default.
- W2330763603 cites W1998195598 @default.
- W2330763603 cites W1999064468 @default.
- W2330763603 cites W2007727729 @default.
- W2330763603 cites W2010601153 @default.
- W2330763603 cites W2010850820 @default.
- W2330763603 cites W2014226393 @default.
- W2330763603 cites W2021882008 @default.
- W2330763603 cites W2022816128 @default.
- W2330763603 cites W2023517550 @default.
- W2330763603 cites W2024222958 @default.
- W2330763603 cites W2027235566 @default.
- W2330763603 cites W2033555492 @default.
- W2330763603 cites W2036923984 @default.
- W2330763603 cites W2037670359 @default.
- W2330763603 cites W2040071727 @default.
- W2330763603 cites W2052689712 @default.
- W2330763603 cites W2077080652 @default.
- W2330763603 cites W2082175813 @default.
- W2330763603 cites W2091114236 @default.
- W2330763603 cites W2093226717 @default.
- W2330763603 cites W2097800928 @default.
- W2330763603 cites W2102836127 @default.
- W2330763603 cites W2108679917 @default.
- W2330763603 cites W2111724662 @default.
- W2330763603 cites W2118278336 @default.
- W2330763603 cites W2127529738 @default.
- W2330763603 cites W2146473598 @default.
- W2330763603 cites W2155214429 @default.
- W2330763603 cites W2160438933 @default.
- W2330763603 cites W2167279371 @default.
- W2330763603 cites W2171432125 @default.
- W2330763603 cites W2317647124 @default.
- W2330763603 cites W2329049473 @default.
- W2330763603 cites W2334793775 @default.
- W2330763603 doi "https://doi.org/10.1091/mbc.e15-09-0670" @default.
- W2330763603 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4850038" @default.
- W2330763603 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26941335" @default.
- W2330763603 hasPublicationYear "2016" @default.
- W2330763603 type Work @default.
- W2330763603 sameAs 2330763603 @default.
- W2330763603 citedByCount "20" @default.
- W2330763603 countsByYear W23307636032017 @default.
- W2330763603 countsByYear W23307636032018 @default.
- W2330763603 countsByYear W23307636032019 @default.
- W2330763603 countsByYear W23307636032020 @default.
- W2330763603 countsByYear W23307636032021 @default.
- W2330763603 countsByYear W23307636032022 @default.
- W2330763603 countsByYear W23307636032023 @default.
- W2330763603 crossrefType "journal-article" @default.
- W2330763603 hasAuthorship W2330763603A5001426883 @default.
- W2330763603 hasAuthorship W2330763603A5012487815 @default.
- W2330763603 hasAuthorship W2330763603A5025062231 @default.
- W2330763603 hasAuthorship W2330763603A5025713245 @default.
- W2330763603 hasAuthorship W2330763603A5036826295 @default.
- W2330763603 hasAuthorship W2330763603A5086804597 @default.
- W2330763603 hasAuthorship W2330763603A5087136130 @default.
- W2330763603 hasBestOaLocation W23307636031 @default.
- W2330763603 hasConcept C11960822 @default.
- W2330763603 hasConcept C126619667 @default.
- W2330763603 hasConcept C151730666 @default.
- W2330763603 hasConcept C207332259 @default.
- W2330763603 hasConcept C2779343474 @default.
- W2330763603 hasConcept C62478195 @default.
- W2330763603 hasConcept C86803240 @default.
- W2330763603 hasConcept C95444343 @default.
- W2330763603 hasConceptScore W2330763603C11960822 @default.
- W2330763603 hasConceptScore W2330763603C126619667 @default.
- W2330763603 hasConceptScore W2330763603C151730666 @default.
- W2330763603 hasConceptScore W2330763603C207332259 @default.
- W2330763603 hasConceptScore W2330763603C2779343474 @default.
- W2330763603 hasConceptScore W2330763603C62478195 @default.
- W2330763603 hasConceptScore W2330763603C86803240 @default.
- W2330763603 hasConceptScore W2330763603C95444343 @default.
- W2330763603 hasIssue "9" @default.
- W2330763603 hasLocation W23307636031 @default.