FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2330786563> ?p ?o ?g. }

• W2330786563 endingPage "992" @default.
• W2330786563 startingPage "992" @default.
• W2330786563 abstract "Introduction: Kidney transplantation is the best therapeutic option for HCV-positive patient with terminal chronic renal failure. However, there is limited and contradictory information on the impact that induction therapy with biological agents may have in this risk group. Aim of the study: Analyze the mid-term efficacy and safety of the induction with biologics (lymphocyte-depleting antibodies or anti-CD25 antibodies) in kidney transplant patients with anti-HCV antibodies positive, in terms of patient survival, graft survival and outcome of liver disease. Patients and methods: Retrospective observational study, based on the analysis of the clinical charts of HCV positive kidney recipients (EIA 1,2,3) at the moment of transplantation (TX) receiving a kidney graft in two Spanish units from March 1990 to March 2007, with follow-up until May 2007. 465 patients who met the inclusion criteria (anti-HCV antibodies positive at the moment of transplantation), and none of the exclusion criteria (HBsAg (+), IFN before Tx, previous or simultaneous transplant of a non-kidney graft), 301 did not receive induction therapy (Group I), 117 were treated with ATG, OKT3 or Timoglobuline ® (Group II), and 47 were treated with anti-CD25 antibodies (Group III). Induction therapy is only applied in patients with a high-immunological risk. Results: The induction with biological agents were not identified as an independent risk factor for the death of the patient (OR = 0, 869, 95% CI 0, 552-1, 369, p = 0, 545) being the 3-years patient survival of 91%, 92% and 93% in the three groups respectively (p = 0. 597). No patient died due to liver disease in groups II and III, and only five did so in group I. The death-censored graft survival to 3 years was similar between groups: 83% group I; 76% Group II; 81% Group III respectively (p = 0. 565). In addition, in the multivariate analysis, induction therapy was not an independent risk factor for graft loss among HCV-positive patients (O = 0. 877, CI 95% 0.646-1.192, p = 0. 403). Also, there were no significant differences in the evolution of ALT post-transplant levels, or in the incidence of postransplant severe clinical liver disease. Conclusion: Our data suggest that induction with biologics in HCV-positive kidney transplant patients with high-immunological risk, is related to a favorable mid-term results with regard to the graft survival, patient survival and without a negative impact on the clinical course of liver disease." @default.
• W2330786563 created "2016-06-24" @default.
• W2330786563 creator A5015374995 @default.
• W2330786563 creator A5037664174 @default.
• W2330786563 creator A5040530313 @default.
• W2330786563 creator A5051534496 @default.
• W2330786563 creator A5055415519 @default.
• W2330786563 creator A5056329949 @default.
• W2330786563 creator A5062816249 @default.
• W2330786563 creator A5083192004 @default.
• W2330786563 date "2012-11-01" @default.
• W2330786563 modified "2023-09-23" @default.
• W2330786563 title "Impact of Biologics for Induction in Kidney Transplant Patients with a Positive Serology for Hepatitis C" @default.
• W2330786563 doi "https://doi.org/10.1097/00007890-201211271-01959" @default.
• W2330786563 hasPublicationYear "2012" @default.
• W2330786563 type Work @default.
• W2330786563 sameAs 2330786563 @default.
• W2330786563 citedByCount "0" @default.
• W2330786563 crossrefType "journal-article" @default.
• W2330786563 hasAuthorship W2330786563A5015374995 @default.
• W2330786563 hasAuthorship W2330786563A5037664174 @default.
• W2330786563 hasAuthorship W2330786563A5040530313 @default.
• W2330786563 hasAuthorship W2330786563A5051534496 @default.
• W2330786563 hasAuthorship W2330786563A5055415519 @default.
• W2330786563 hasAuthorship W2330786563A5056329949 @default.
• W2330786563 hasAuthorship W2330786563A5062816249 @default.
• W2330786563 hasAuthorship W2330786563A5083192004 @default.
• W2330786563 hasBestOaLocation W23307865631 @default.
• W2330786563 hasConcept C126322002 @default.
• W2330786563 hasConcept C159654299 @default.
• W2330786563 hasConcept C203014093 @default.
• W2330786563 hasConcept C2522874641 @default.
• W2330786563 hasConcept C2776455275 @default.
• W2330786563 hasConcept C2777410769 @default.
• W2330786563 hasConcept C2778653478 @default.
• W2330786563 hasConcept C2779978075 @default.
• W2330786563 hasConcept C2780091579 @default.
• W2330786563 hasConcept C2780303639 @default.
• W2330786563 hasConcept C2780593183 @default.
• W2330786563 hasConcept C2911091166 @default.
• W2330786563 hasConcept C45189115 @default.
• W2330786563 hasConcept C71924100 @default.
• W2330786563 hasConcept C90924648 @default.
• W2330786563 hasConceptScore W2330786563C126322002 @default.
• W2330786563 hasConceptScore W2330786563C159654299 @default.
• W2330786563 hasConceptScore W2330786563C203014093 @default.
• W2330786563 hasConceptScore W2330786563C2522874641 @default.
• W2330786563 hasConceptScore W2330786563C2776455275 @default.
• W2330786563 hasConceptScore W2330786563C2777410769 @default.
• W2330786563 hasConceptScore W2330786563C2778653478 @default.
• W2330786563 hasConceptScore W2330786563C2779978075 @default.
• W2330786563 hasConceptScore W2330786563C2780091579 @default.
• W2330786563 hasConceptScore W2330786563C2780303639 @default.
• W2330786563 hasConceptScore W2330786563C2780593183 @default.
• W2330786563 hasConceptScore W2330786563C2911091166 @default.
• W2330786563 hasConceptScore W2330786563C45189115 @default.
• W2330786563 hasConceptScore W2330786563C71924100 @default.
• W2330786563 hasConceptScore W2330786563C90924648 @default.
• W2330786563 hasIssue "10S" @default.
• W2330786563 hasLocation W23307865631 @default.
• W2330786563 hasOpenAccess W2330786563 @default.
• W2330786563 hasPrimaryLocation W23307865631 @default.
• W2330786563 hasRelatedWork W177744588 @default.
• W2330786563 hasRelatedWork W2092810138 @default.
• W2330786563 hasRelatedWork W2378019284 @default.
• W2330786563 hasRelatedWork W2594335794 @default.
• W2330786563 hasRelatedWork W2791479853 @default.
• W2330786563 hasRelatedWork W2997791083 @default.
• W2330786563 hasRelatedWork W3012164560 @default.
• W2330786563 hasRelatedWork W3033926193 @default.
• W2330786563 hasRelatedWork W3132018655 @default.
• W2330786563 hasRelatedWork W4249379374 @default.
• W2330786563 hasVolume "94" @default.
• W2330786563 isParatext "false" @default.
• W2330786563 isRetracted "false" @default.
• W2330786563 magId "2330786563" @default.
• W2330786563 workType "article" @default.