Matches in SemOpenAlex for { <https://semopenalex.org/work/W23308056> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W23308056 endingPage "30" @default.
- W23308056 startingPage "125" @default.
- W23308056 abstract "The effects of single oral and intraperitoneal (i.p.) overdoses of paracetamol (500 mg/kg) were studied in mice. The correlation between hepatocellular damage and plasma levels of paracetamol metabolites derived from the oxidative pathway were also investigated. Animals were killed at different intervals (1, 2.5 and 6 h) after drug administration. Plasma concentrations of paracetamol and its sulphate, glucuronide, cysteine and mercapturate conjugates were determined by HPLC. Paracetamol plasma levels were significantly higher at 1 and 2.5 h after i.p. administration as compared to oral administration (p = 0.01 and p = 0.02, respectively). Plasma levels of mercapturic acid conjugate were significantly higher at 6 h after i.p. administration (p = 0.04). After 6 h, animals given oral paracetamol showed significantly less necrosis than animals given i.p. paracetamol (p = 0.03). Plasma levels of mercapturate conjugate at 6 h showed a significant correlation with the severity of liver necrosis (r = 0.64; p = 0.02). The results suggest that i.p. paracetamol seems to be more adequate for hepatotoxicity studies in mice." @default.
- W23308056 created "2016-06-24" @default.
- W23308056 creator A5002024290 @default.
- W23308056 creator A5003158355 @default.
- W23308056 creator A5026886450 @default.
- W23308056 creator A5027911930 @default.
- W23308056 creator A5088654937 @default.
- W23308056 date "1993-03-01" @default.
- W23308056 modified "2023-10-18" @default.
- W23308056 title "Liver damage and plasma concentrations of paracetamol and its metabolites after paracetamol overdosage in mice." @default.
- W23308056 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8487595" @default.
- W23308056 hasPublicationYear "1993" @default.
- W23308056 type Work @default.
- W23308056 sameAs 23308056 @default.
- W23308056 citedByCount "0" @default.
- W23308056 crossrefType "journal-article" @default.
- W23308056 hasAuthorship W23308056A5002024290 @default.
- W23308056 hasAuthorship W23308056A5003158355 @default.
- W23308056 hasAuthorship W23308056A5026886450 @default.
- W23308056 hasAuthorship W23308056A5027911930 @default.
- W23308056 hasAuthorship W23308056A5088654937 @default.
- W23308056 hasConcept C181389837 @default.
- W23308056 hasConcept C185592680 @default.
- W23308056 hasConcept C2777056448 @default.
- W23308056 hasConcept C2777477808 @default.
- W23308056 hasConcept C2778722691 @default.
- W23308056 hasConcept C2779186261 @default.
- W23308056 hasConcept C3020079912 @default.
- W23308056 hasConcept C55493867 @default.
- W23308056 hasConcept C71924100 @default.
- W23308056 hasConcept C98274493 @default.
- W23308056 hasConceptScore W23308056C181389837 @default.
- W23308056 hasConceptScore W23308056C185592680 @default.
- W23308056 hasConceptScore W23308056C2777056448 @default.
- W23308056 hasConceptScore W23308056C2777477808 @default.
- W23308056 hasConceptScore W23308056C2778722691 @default.
- W23308056 hasConceptScore W23308056C2779186261 @default.
- W23308056 hasConceptScore W23308056C3020079912 @default.
- W23308056 hasConceptScore W23308056C55493867 @default.
- W23308056 hasConceptScore W23308056C71924100 @default.
- W23308056 hasConceptScore W23308056C98274493 @default.
- W23308056 hasIssue "2" @default.
- W23308056 hasLocation W233080561 @default.
- W23308056 hasOpenAccess W23308056 @default.
- W23308056 hasPrimaryLocation W233080561 @default.
- W23308056 hasRelatedWork W1516796020 @default.
- W23308056 hasRelatedWork W172883796 @default.
- W23308056 hasRelatedWork W1991414333 @default.
- W23308056 hasRelatedWork W1999172666 @default.
- W23308056 hasRelatedWork W2019460789 @default.
- W23308056 hasRelatedWork W2405226471 @default.
- W23308056 hasRelatedWork W2414821742 @default.
- W23308056 hasRelatedWork W2415089412 @default.
- W23308056 hasRelatedWork W2796717224 @default.
- W23308056 hasRelatedWork W3112763513 @default.
- W23308056 hasVolume "15" @default.
- W23308056 isParatext "false" @default.
- W23308056 isRetracted "false" @default.
- W23308056 magId "23308056" @default.
- W23308056 workType "article" @default.