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• W2330820926 abstract "Background: Caffeine is the most widely consumed psychoactive substance in the world, even during pregnancy. Its stimulatory effects are mainly due to antagonism of adenosine actions by blocking adenosine A1 and A2A receptors. Previous studies have shown that caffeine can cross the placenta and therefore modulate these receptors not only in the fetal brain but also in the heart. Methods: In the present work, the effect of caffeine chronically consumed during pregnancy on A1 and A2A receptors in Wistar rat heart, from both mothers and their fetuses, were studied using radioligand binding, Western-blotting, and adenylyl cyclase activity assays, as well as reverse transcription polymerase chain reaction. Results: Caffeine did not significantly alter A1R neither at protein nor at gene expression level in both the maternal and fetal heart. On the contrary, A2AR significantly decreased in the maternal heart, although mRNA was not affected. Gi and Gs proteins were also preserved. Finally, A1R-mediated inhibition of adenylyl cyclase activity did not change in the maternal heart, but A2AR mediated stimulation of this enzymatic activity significantly decreased according to the detected loss of this receptor. Conclusions: Opposite to the downregulation and desensitization of the A1R/AC pathway previously reported in the brain, these results show that this pathway is not affected in rat heart after caffeine exposure during pregnancy. In addition, A2AR is downregulated and desensitized in the maternal heart, suggesting a differential modulation of these receptor-mediated pathways by caffeine." @default.
• W2330820926 created "2016-06-24" @default.
• W2330820926 creator A5015818040 @default.
• W2330820926 creator A5028519120 @default.
• W2330820926 creator A5038744985 @default.
• W2330820926 date "2014-12-01" @default.
• W2330820926 modified "2023-09-27" @default.
• W2330820926 title "Effect of Caffeine Chronically Consumed During Pregnancy on Adenosine A₁ and A_2A Receptors Signaling in Both Maternal and Fetal Heart from Wistar Rats" @default.
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• W2330820926 doi "https://doi.org/10.1089/jcr.2014.0010" @default.
• W2330820926 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4267408" @default.
• W2330820926 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25538864" @default.
• W2330820926 hasPublicationYear "2014" @default.
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