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- W2330821673 abstract "In an earlier paper it was shown that a decrease in the pH of the blood, produced prior to the administration of lethal doses of strychnine, prevented violent tetanus and death. It was considered important to try the reciprocal experiment, that is, the effect of administering alkali to dogs that had previously received a lethal dose of curare. Dogs used in this experiment received, intravenously, 5.7 mg. of curare per kilo of body weight. The drug used was the product of Burroughs, Wellcome & Co. Eight or 10 minutes after injection, when paralysis of the muscles, except the respiratory muscles, had appeared, a 5% solution of NaHCO3 was injected intravenously. Complete recovery occurred within 15 minutes after approximately 3.0 gm. of NaHCO3 had been introduced. The “curare effect” did not reappear. At the onset of muscle paralysis the pH and CO2 capacity begin to fall. The acidosis produced evidently augments the effect of curare but is not, in itself, sufficiently pronounced to produce coma. Introduction of NaHCO3 not only corrects anoxemia but also possibly neutralizes the curare effect at the myo-neural junction." @default.
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- W2330821673 date "1928-12-01" @default.
- W2330821673 modified "2023-09-26" @default.
- W2330821673 title "Effect of Intravenous Injections of Alkali on Physiological Action of Curare." @default.
- W2330821673 doi "https://doi.org/10.3181/00379727-26-4207" @default.
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