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- W2330832291 abstract "Objective: To explore the role and molecular mechanism of monocyte chemotactic protein-1 in angiotensin II-induced proliferation of rat aortic smooth muscle cells. Design and methods: CCK-8 assay was used to detect the proliferation of vascular smooth muscle cells. MCP-1 mRNA levels in rat aortic smooth muscle cells exposed to different concentrations of Ang II were determined by RT-PCR. MCP-1 secretion levels in the supernatant collected at indicated time were evaluated by ELISA. CCR2 expression and distribution were detected by Immunofluorescence in rat aortic smooth muscle cells. After rat VSMCs were pre-treated by 10 μM U0126 or SP600125 with or without 1000 nM Ang II for 12 hours, western blot was used to determine protein levels of Pi-ERK, ERK, Pi-JNK, JNK and MCP-1. Results: 1000 nM Angiotensin II could stimulate rat aortic smooth muscle cells proliferation by angiotensin II type 1 receptor (AT1R). Simultaneously, angiotensin II increased monocyte chemotactic protein-1 expression and secretion in a dose-and time-dependent manner, through activation of its receptor AT1R. Then, monocyte chemotactic protein-1 contributed to Ang II-induced cells proliferation by CCR2. Furthermore, we found that intracellular ERK and JNK signaling molecules were implicated in angiotensin II-stimulated monocyte chemotactic protein-1 expression and proliferation mediated by monocyte chemotactic protein-1. Conclusions: These data indicated MCP-1 increase indirectly promoted Ang II-induced rat aortic smooth muscle cells proliferation. ERK and JNK signal-dependent pathways were implicated in Ang II-stimulated MCP-1 expression in rat aortic smooth muscle cells." @default.
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- W2330832291 date "2012-09-01" @default.
- W2330832291 modified "2023-09-27" @default.
- W2330832291 title "1010 MONOCYTE CHEMOATTRACTANT PROTEIN-1 MEDIATES ANGIOTENSIN II-INDUCED VASCULAR SMOOTH MUSCLE CELL PROLIFERATION VIA SAPK/JNK AND ERK1/2" @default.
- W2330832291 doi "https://doi.org/10.1097/01.hjh.0000420955.72546.d7" @default.
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