Matches in SemOpenAlex for { <https://semopenalex.org/work/W2330867747> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2330867747 endingPage "S562" @default.
- W2330867747 startingPage "S561" @default.
- W2330867747 abstract "DNA topoisomerase II (Topo II) is an essential nuclear enzyme and a validated target for anticancer agent screening. CS1, a novel 2-phenylnaphthalene, had potent cytotoxicity against nine tested tumor cell lines and showed 6–10-fold less toxicity against normal cell lines compared with etoposide. In addition, CS1 showed potential anti-multidrug resistance capabilities. kDNA decatenation, DNA relaxation and cleavage complex assays indicated that CS1 acted as a nonintercalating topoisomerase IIα (Topo IIα) inhibitor by stabilizing the DNA-Topo IIα cleavage complex. CS1 also induced DNA breaks in MDA-MB-231 cells evidenced by comet tails and the accumulation of γH2AX foci. The ability of CS1 in inducing DNA breaks mediated by Topo II resulted in G2/M phase arrest and apoptosis. Moreover, CS1 exhibited dramatic in vivo antitumor activity and lower toxicity compared with etoposide. This work supports the development of CS1 as a promising candidate for the treatment of cancer by targeting Topo IIα." @default.
- W2330867747 created "2016-06-24" @default.
- W2330867747 creator A5001052785 @default.
- W2330867747 creator A5001695846 @default.
- W2330867747 creator A5067339350 @default.
- W2330867747 creator A5068547755 @default.
- W2330867747 creator A5069958553 @default.
- W2330867747 creator A5079964978 @default.
- W2330867747 date "2014-10-01" @default.
- W2330867747 modified "2023-09-27" @default.
- W2330867747 title "P.3.d.066 Hyperprolactinemia, psychopathology, and sexual functioning in schizophrenic patients" @default.
- W2330867747 doi "https://doi.org/10.1016/s0924-977x(14)70899-5" @default.
- W2330867747 hasPublicationYear "2014" @default.
- W2330867747 type Work @default.
- W2330867747 sameAs 2330867747 @default.
- W2330867747 citedByCount "0" @default.
- W2330867747 crossrefType "journal-article" @default.
- W2330867747 hasAuthorship W2330867747A5001052785 @default.
- W2330867747 hasAuthorship W2330867747A5001695846 @default.
- W2330867747 hasAuthorship W2330867747A5067339350 @default.
- W2330867747 hasAuthorship W2330867747A5068547755 @default.
- W2330867747 hasAuthorship W2330867747A5069958553 @default.
- W2330867747 hasAuthorship W2330867747A5079964978 @default.
- W2330867747 hasConcept C109316439 @default.
- W2330867747 hasConcept C143425029 @default.
- W2330867747 hasConcept C147897179 @default.
- W2330867747 hasConcept C151730666 @default.
- W2330867747 hasConcept C153911025 @default.
- W2330867747 hasConcept C175156509 @default.
- W2330867747 hasConcept C185592680 @default.
- W2330867747 hasConcept C190283241 @default.
- W2330867747 hasConcept C202751555 @default.
- W2330867747 hasConcept C207001950 @default.
- W2330867747 hasConcept C2776694085 @default.
- W2330867747 hasConcept C2778119113 @default.
- W2330867747 hasConcept C43369102 @default.
- W2330867747 hasConcept C502942594 @default.
- W2330867747 hasConcept C54355233 @default.
- W2330867747 hasConcept C552990157 @default.
- W2330867747 hasConcept C55493867 @default.
- W2330867747 hasConcept C86803240 @default.
- W2330867747 hasConceptScore W2330867747C109316439 @default.
- W2330867747 hasConceptScore W2330867747C143425029 @default.
- W2330867747 hasConceptScore W2330867747C147897179 @default.
- W2330867747 hasConceptScore W2330867747C151730666 @default.
- W2330867747 hasConceptScore W2330867747C153911025 @default.
- W2330867747 hasConceptScore W2330867747C175156509 @default.
- W2330867747 hasConceptScore W2330867747C185592680 @default.
- W2330867747 hasConceptScore W2330867747C190283241 @default.
- W2330867747 hasConceptScore W2330867747C202751555 @default.
- W2330867747 hasConceptScore W2330867747C207001950 @default.
- W2330867747 hasConceptScore W2330867747C2776694085 @default.
- W2330867747 hasConceptScore W2330867747C2778119113 @default.
- W2330867747 hasConceptScore W2330867747C43369102 @default.
- W2330867747 hasConceptScore W2330867747C502942594 @default.
- W2330867747 hasConceptScore W2330867747C54355233 @default.
- W2330867747 hasConceptScore W2330867747C552990157 @default.
- W2330867747 hasConceptScore W2330867747C55493867 @default.
- W2330867747 hasConceptScore W2330867747C86803240 @default.
- W2330867747 hasLocation W23308677471 @default.
- W2330867747 hasOpenAccess W2330867747 @default.
- W2330867747 hasPrimaryLocation W23308677471 @default.
- W2330867747 hasRelatedWork W1535680595 @default.
- W2330867747 hasRelatedWork W1971840717 @default.
- W2330867747 hasRelatedWork W1974539652 @default.
- W2330867747 hasRelatedWork W1977754686 @default.
- W2330867747 hasRelatedWork W1980092410 @default.
- W2330867747 hasRelatedWork W1987239902 @default.
- W2330867747 hasRelatedWork W1993553978 @default.
- W2330867747 hasRelatedWork W2065428450 @default.
- W2330867747 hasRelatedWork W2067141850 @default.
- W2330867747 hasRelatedWork W2953225876 @default.
- W2330867747 hasVolume "24" @default.
- W2330867747 isParatext "false" @default.
- W2330867747 isRetracted "false" @default.
- W2330867747 magId "2330867747" @default.
- W2330867747 workType "article" @default.