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- W2330880707 abstract "AbstractBackground: Smoking has been perceived to increase the levels of carcinogenic and inflammatory mediatorsthereby promoting presumably malignant and proinflammatory tissue destruction via activating proteolytic enzymessuch as matrix metalloproteinases (MMPs) and their regulators. We studied the effect of smoking on the diagnosticability of serum MMP-8-IFMA and TIMP-1-ELISA analysis to recognize patients with acute coronary syndrome(ACS).Methods: The case-control population (n=605) comprised 291 patients with diagnosed acute myocardialinfarction (AMI) or unstable angina pectoris (UAP) and 314 healthy control individuals. The case and the controlgroup included 55 and 66 smoking subjects, respectively.Results: Smoking increased the MMP-8, but not the TIMP-1, concentration in both the control and the AMIgroup. MMP-8 concentration, and consequently MMP-8/TIMP-1, distinguished the cases from the controls accuratelyin the ROC analysis, but smoking decreased the AUCs in every category. The MMP-8 concentration produced anAUC (95% CI, p-value) for ACS of 0.771 (0.723-0.818, p<0.001) and 0.684 (0.581-0.787, p=0.001) for non-smokersand smokers, respectively. Similarly, the multivariate logistic regression model indicated that smoking decreased theassociation of MMP-8 with ACS. The OR (95% CI, p-value) of MMP-8 for ACS was 8.1 (per ng/ml log-transformedunit increase, 5.0-13.1, p<0.001) and 2.8 (1.1-7.0, p=0.025) for non-smokers and smokers, respectively.Conclusions: One of the most important risk factors for ACS, smoking, decreases the diagnostic ability of MMP-8 concentration and MMP-8/TIMP-1 ratio. This must be taken account if these serum determinations are used asbiomarkers of the risk for cardiovascular diseases." @default.
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- W2330880707 date "2013-01-01" @default.
- W2330880707 modified "2023-10-18" @default.
- W2330880707 title "The Effect of Smoking on Diagnostic Value of Serum Matrix Metalloproteinase-8 in Acute Coronary Syndrome" @default.
- W2330880707 doi "https://doi.org/10.4172/2155-9929.s4-002" @default.
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