Matches in SemOpenAlex for { <https://semopenalex.org/work/W2330903029> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2330903029 endingPage "108" @default.
- W2330903029 startingPage "107" @default.
- W2330903029 abstract "In a previous study, we demonstrated that in rat striatal synaptosomes, methamphetamine (METH)-induced reactive oxygen species (ROS) production was prevented by methyllycaconitine (MLA), a specific antagonist of α7 neuronal nicotinic acetylcholine receptors (α7 nAChR). The aim of this study was to test the influence of MLA on acute METH effects and neurotoxicity in mice, using both in vivo and in vitro models. MLA inhibited METH-induced climbing behavior by 50%. Acute effects after 30-min preincubation with 1 μM METH also included a decrease in striatal synaptosome dopamine (DA) uptake, which was prevented by MLA. METH-induced neurotoxicity was assessed in vivo in terms of loss of striatal dopaminergic terminals (73%) and of tyrosine hydroxylase levels (by 90%) at 72 h post-treatment, which was significantly attenuated by MLA. Microglial activation [measured as 1-(2-chlorophenyl)-<i>N</i>-methyl-<i>N</i>-(1-methylpropyl)-3-isoquinolinecarboxamide binding] was also present at 24 h post-treatment and was fully prevented by MLA, tending to confirm its neuroprotective activity. MLA had no effect on METH-induced hyperthermia. Additionally, flow cytometry assays showed that METH-induced ROS generation occurs inside synaptosomes from mouse striatum. This effect implied release of vesicular DA and was calcium-, neuronal nitric-oxide synthase-, and protein kinase C-dependent. MLA and α-bungarotoxin, but not dihydro-β-erythroidine (an antagonist that blocks nAChR-containing β2 subunits), fully prevented METH-induced ROS production without affecting vesicular DA uptake. The importance of this study lies not only in the neuroprotective effect elicited by the blockade of the α7 nicotinic receptors by MLA but also in that it proposes a new mechanism with which to study METH-induced acute and long-term effects." @default.
- W2330903029 created "2016-06-24" @default.
- W2330903029 creator A5023375373 @default.
- W2330903029 date "1863-07-01" @default.
- W2330903029 modified "2023-09-25" @default.
- W2330903029 title "III Proceedings of Learned Societies: On the long spectrum of electric light" @default.
- W2330903029 doi "https://doi.org/10.2475/ajs.s2-36.106.107" @default.
- W2330903029 hasPublicationYear "1863" @default.
- W2330903029 type Work @default.
- W2330903029 sameAs 2330903029 @default.
- W2330903029 citedByCount "0" @default.
- W2330903029 crossrefType "journal-article" @default.
- W2330903029 hasAuthorship W2330903029A5023375373 @default.
- W2330903029 hasConcept C134018914 @default.
- W2330903029 hasConcept C137183658 @default.
- W2330903029 hasConcept C150903083 @default.
- W2330903029 hasConcept C159167319 @default.
- W2330903029 hasConcept C166940927 @default.
- W2330903029 hasConcept C170493617 @default.
- W2330903029 hasConcept C178790620 @default.
- W2330903029 hasConcept C181199279 @default.
- W2330903029 hasConcept C185592680 @default.
- W2330903029 hasConcept C188987157 @default.
- W2330903029 hasConcept C207001950 @default.
- W2330903029 hasConcept C25498285 @default.
- W2330903029 hasConcept C2775910092 @default.
- W2330903029 hasConcept C2776885963 @default.
- W2330903029 hasConcept C2778122271 @default.
- W2330903029 hasConcept C2779491297 @default.
- W2330903029 hasConcept C2779570518 @default.
- W2330903029 hasConcept C2779989194 @default.
- W2330903029 hasConcept C2780062018 @default.
- W2330903029 hasConcept C2780114369 @default.
- W2330903029 hasConcept C2780374058 @default.
- W2330903029 hasConcept C2780376393 @default.
- W2330903029 hasConcept C29730261 @default.
- W2330903029 hasConcept C513476851 @default.
- W2330903029 hasConcept C521977710 @default.
- W2330903029 hasConcept C55493867 @default.
- W2330903029 hasConcept C86803240 @default.
- W2330903029 hasConcept C98274493 @default.
- W2330903029 hasConceptScore W2330903029C134018914 @default.
- W2330903029 hasConceptScore W2330903029C137183658 @default.
- W2330903029 hasConceptScore W2330903029C150903083 @default.
- W2330903029 hasConceptScore W2330903029C159167319 @default.
- W2330903029 hasConceptScore W2330903029C166940927 @default.
- W2330903029 hasConceptScore W2330903029C170493617 @default.
- W2330903029 hasConceptScore W2330903029C178790620 @default.
- W2330903029 hasConceptScore W2330903029C181199279 @default.
- W2330903029 hasConceptScore W2330903029C185592680 @default.
- W2330903029 hasConceptScore W2330903029C188987157 @default.
- W2330903029 hasConceptScore W2330903029C207001950 @default.
- W2330903029 hasConceptScore W2330903029C25498285 @default.
- W2330903029 hasConceptScore W2330903029C2775910092 @default.
- W2330903029 hasConceptScore W2330903029C2776885963 @default.
- W2330903029 hasConceptScore W2330903029C2778122271 @default.
- W2330903029 hasConceptScore W2330903029C2779491297 @default.
- W2330903029 hasConceptScore W2330903029C2779570518 @default.
- W2330903029 hasConceptScore W2330903029C2779989194 @default.
- W2330903029 hasConceptScore W2330903029C2780062018 @default.
- W2330903029 hasConceptScore W2330903029C2780114369 @default.
- W2330903029 hasConceptScore W2330903029C2780374058 @default.
- W2330903029 hasConceptScore W2330903029C2780376393 @default.
- W2330903029 hasConceptScore W2330903029C29730261 @default.
- W2330903029 hasConceptScore W2330903029C513476851 @default.
- W2330903029 hasConceptScore W2330903029C521977710 @default.
- W2330903029 hasConceptScore W2330903029C55493867 @default.
- W2330903029 hasConceptScore W2330903029C86803240 @default.
- W2330903029 hasConceptScore W2330903029C98274493 @default.
- W2330903029 hasIssue "106" @default.
- W2330903029 hasLocation W23309030291 @default.
- W2330903029 hasOpenAccess W2330903029 @default.
- W2330903029 hasPrimaryLocation W23309030291 @default.
- W2330903029 hasRelatedWork W1978889063 @default.
- W2330903029 hasRelatedWork W1988440685 @default.
- W2330903029 hasRelatedWork W1995566079 @default.
- W2330903029 hasRelatedWork W2003491520 @default.
- W2330903029 hasRelatedWork W2066020315 @default.
- W2330903029 hasRelatedWork W2080558867 @default.
- W2330903029 hasRelatedWork W2092433873 @default.
- W2330903029 hasRelatedWork W2128980675 @default.
- W2330903029 hasRelatedWork W2168088912 @default.
- W2330903029 hasRelatedWork W2290419729 @default.
- W2330903029 hasVolume "s2-36" @default.
- W2330903029 isParatext "false" @default.
- W2330903029 isRetracted "false" @default.
- W2330903029 magId "2330903029" @default.
- W2330903029 workType "article" @default.