FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2330923897> ?p ?o ?g. }

• W2330923897 endingPage "1116" @default.
• W2330923897 startingPage "1111" @default.
• W2330923897 abstract "Eighty-nine patients with untreated primary neuroblastomas were studied to determine the relation between the number of copies of the N-myc oncogene and survival without disease progression. Genomic amplification (3 to 300 copies) of N-myc was detected in 2 of 16 tumors in Stage II, 13 of 20 in Stage III, and 19 of 40 in Stage IV; in contrast, 8 Stage I and 5 Stage IV-S tumors all had 1 copy of the gene (P<0.01). Analysis of progression-free survival in all patients revealed that amplification of N-myc was associated with the worst prognosis (P<0.0001); the estimated progression-free survival at 18 months was 70 per cent, 30 per cent, and 5 per cent for patients whose tumors had 1, 3 to 10, or more than 10 N-myc copies, respectively. Of 16 Stage II tumors, 2 with amplification metastasized, whereas only 1 of 14 without amplification did so (P = 0.03). Stage IV tumors with amplification progressed most rapidly: nine months after diagnosis the estimated progression-free survival was 61 per cent, 47 per cent, and 0 per cent in patients whose tumors had 1, 3 to 10, or more than 10 copies, respectively (P<0.0001). These results suggest that genomic amplification of N-myc may have a key role in determining the aggressiveness of neuroblastomas. (N Engl J Med 1985; 313: 1111–6.)" @default.
• W2330923897 created "2016-06-24" @default.
• W2330923897 creator A5004950779 @default.
• W2330923897 creator A5028334828 @default.
• W2330923897 creator A5033608060 @default.
• W2330923897 creator A5040645953 @default.
• W2330923897 creator A5051208048 @default.
• W2330923897 creator A5067145358 @default.
• W2330923897 creator A5091382993 @default.
• W2330923897 date "1985-10-31" @default.
• W2330923897 modified "2023-10-06" @default.
• W2330923897 title "Association of Multiple Copies of the N-<i>myc</i>Oncogene with Rapid Progression of Neuroblastomas" @default.
• W2330923897 cites W168418620 @default.
• W2330923897 cites W1773967934 @default.
• W2330923897 cites W1926885922 @default.
• W2330923897 cites W1943628059 @default.
• W2330923897 cites W1971242318 @default.
• W2330923897 cites W1973071934 @default.
• W2330923897 cites W1973979381 @default.
• W2330923897 cites W1977768398 @default.
• W2330923897 cites W1987234748 @default.
• W2330923897 cites W1993610674 @default.
• W2330923897 cites W1995337883 @default.
• W2330923897 cites W2011795445 @default.
• W2330923897 cites W2012219845 @default.
• W2330923897 cites W2012399090 @default.
• W2330923897 cites W2014165281 @default.
• W2330923897 cites W2016620103 @default.
• W2330923897 cites W2024280594 @default.
• W2330923897 cites W2024545138 @default.
• W2330923897 cites W2028957701 @default.
• W2330923897 cites W2030534890 @default.
• W2330923897 cites W2038252730 @default.
• W2330923897 cites W2039061731 @default.
• W2330923897 cites W2046302025 @default.
• W2330923897 cites W2048299411 @default.
• W2330923897 cites W2048324748 @default.
• W2330923897 cites W2056120923 @default.
• W2330923897 cites W2064428081 @default.
• W2330923897 cites W2073101093 @default.
• W2330923897 cites W2073557222 @default.
• W2330923897 cites W2085214231 @default.
• W2330923897 cites W2093310753 @default.
• W2330923897 cites W2180795626 @default.
• W2330923897 cites W2481746652 @default.
• W2330923897 cites W3041047318 @default.
• W2330923897 doi "https://doi.org/10.1056/nejm198510313131802" @default.
• W2330923897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4047115" @default.
• W2330923897 hasPublicationYear "1985" @default.
• W2330923897 type Work @default.
• W2330923897 sameAs 2330923897 @default.
• W2330923897 citedByCount "1901" @default.
• W2330923897 countsByYear W23309238972012 @default.
• W2330923897 countsByYear W23309238972013 @default.
• W2330923897 countsByYear W23309238972014 @default.
• W2330923897 countsByYear W23309238972015 @default.
• W2330923897 countsByYear W23309238972016 @default.
• W2330923897 countsByYear W23309238972017 @default.
• W2330923897 countsByYear W23309238972018 @default.
• W2330923897 countsByYear W23309238972019 @default.
• W2330923897 countsByYear W23309238972020 @default.
• W2330923897 countsByYear W23309238972021 @default.
• W2330923897 countsByYear W23309238972022 @default.
• W2330923897 countsByYear W23309238972023 @default.
• W2330923897 crossrefType "journal-article" @default.
• W2330923897 hasAuthorship W2330923897A5004950779 @default.
• W2330923897 hasAuthorship W2330923897A5028334828 @default.
• W2330923897 hasAuthorship W2330923897A5033608060 @default.
• W2330923897 hasAuthorship W2330923897A5040645953 @default.
• W2330923897 hasAuthorship W2330923897A5051208048 @default.
• W2330923897 hasAuthorship W2330923897A5067145358 @default.
• W2330923897 hasAuthorship W2330923897A5091382993 @default.
• W2330923897 hasConcept C104317684 @default.
• W2330923897 hasConcept C121608353 @default.
• W2330923897 hasConcept C126322002 @default.
• W2330923897 hasConcept C142724271 @default.
• W2330923897 hasConcept C143998085 @default.
• W2330923897 hasConcept C146357865 @default.
• W2330923897 hasConcept C151730666 @default.
• W2330923897 hasConcept C2776715637 @default.
• W2330923897 hasConcept C2777956278 @default.
• W2330923897 hasConcept C2779102060 @default.
• W2330923897 hasConcept C2779256057 @default.
• W2330923897 hasConcept C2780739268 @default.
• W2330923897 hasConcept C2781018059 @default.
• W2330923897 hasConcept C29537977 @default.
• W2330923897 hasConcept C3019894029 @default.
• W2330923897 hasConcept C54355233 @default.
• W2330923897 hasConcept C71924100 @default.
• W2330923897 hasConcept C7602840 @default.
• W2330923897 hasConcept C81885089 @default.
• W2330923897 hasConcept C86803240 @default.
• W2330923897 hasConcept C90924648 @default.
• W2330923897 hasConceptScore W2330923897C104317684 @default.
• W2330923897 hasConceptScore W2330923897C121608353 @default.
• W2330923897 hasConceptScore W2330923897C126322002 @default.
• W2330923897 hasConceptScore W2330923897C142724271 @default.
• W2330923897 hasConceptScore W2330923897C143998085 @default.

• next