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- W2330998265 abstract "To investigate the malignant potential of the T1 sized type-C pulmonary adenocarcinoma (PA), proliferative and invasive growth potentials of the tumor cells were examined. Twenty-one surgically resected cases of type-C PA were selected for this study, each less than 3 cm in the largest dimension and classified as T1. None of these cases had received pre-operative chemotherapy or radiotherapy. Using the Ki-67 labeling index (LI) for tumor cells, which indicates the proliferative growth potential, tumors averaged 6.55±3.52% in the center, and 12.16±4.76% in the periphery. This labeling showed no specific relationship with the tumor dimension or lymph node involvement. The cathepsin D-positive rate, indicative of invasive growth potential, was 42.9% in the center, and 14.3% in the periphery. The cathepsin D-positive rate showed no specific relationship with the tumor dimension, but showed a significant relationship with the level of lymph node involvement. We conclude that the malignant potential of type-C PA depends on cathepsin D expression in tumor cells, rather than the Ki-67 LI." @default.
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- W2330998265 date "2001-01-01" @default.
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- W2330998265 title "Proliferative and Invasive Growth Potentials of Type-C Pulmonary Adenocarcinoma" @default.
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- W2330998265 doi "https://doi.org/10.15369/sujms1989.13.177" @default.
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