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- W2331004885 abstract "Background c-MYC is a proto-oncogene located on 8q24 with well-established critical roles in the development and progression of breast cancer. However, there is relatively little information available on the frequency of its amplification in breast cancer, with widely varying estimates in the literature and only two studies using the gold-standard of fluorescent in situ hybridisation (FISH). Moreover, there is little consensus as to a clinically relevant c-MYC/CEP8 (centromeric region of chromosome 8) ratio in determining patient outcome or response to therapy. Methods We investigated the frequency of c-MYC gene amplification using FISH in formalin fixed, paraffin processed tissues in 16 tissue microarrays from a cohort of 262 patients with operable invasive ductal carcinoma. C-MYC gene and CEP8 region copy number were determined in 20 representative tumour nuclei and a ratio c-MYC/CEP8 calculated. Two different ratios were tested using Kaplan-Meier survival analysis for their prognostic strength; 2.2 as used to determine HER2 gene amplification, and a newly described ratio of 1.3 which co-segregated with outcome. Chi squared analysis was then used to investigate the clinicopathological associations of c-MYC gene amplification Results A c-MYC/CEP8 ratio of 1.3 identified a poor prognostic group in the cohort (HR 2.28, p = 14; 0.006), while a ratio of 2.2 showed only a trend towards significance (p = 14; 0.087). Using a ratio of 1.3, 22.1% of cancers showed c-MYC gene amplification, while 61% were diploid and 16.9% were polysomic. c-MYC gene amplification was associated with larger, grade 3, ER negative, Ki67 high tumours (all p 5 0.05). Furthermore there was a highly significant association with the basal-like phenotype (p = 14; 0.004). Conclusion We have validated that a c-MYC/CEP8 ratio of 1.3 is able to identify a poor prognosis group of breast cancer patients. c-MYC gene amplification is associated with a number of high risk clinicopathological variables." @default.
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- W2331004885 date "2010-01-01" @default.
- W2331004885 modified "2023-09-24" @default.
- W2331004885 title "29. c-MYC gene amplification is associated with a poor prognosis in invasive ductal carcinoma" @default.
- W2331004885 doi "https://doi.org/10.1097/01268031-201042001-00200" @default.
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