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• W2331005864 abstract "The synthesis and the relationship between in vitro and in vivo activities of 6-[(R)-2-[3-(3,4-dihydroxybenzoyl)-3-R1-1-ureido]-2- phenylacetamido]penicillanic acids having C2 approximately 8 alkyl or substituted alkyl groups as the substituents (R1) are described. In this series, 6-[(R)-2-[3-(3,4-dihydroxybenzoyl)-3-(3-hydroxypropyl)-1-ureido] -2-phenylacetamido]penicillanic acid (1b, AO-1100) showed the most potent protective effect on mice in experimental Pseudomonas aeruginosa infections, although it did not have the strongest in vitro activity among the penicillins we synthesized." @default.
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• W2331005864 date "1986-01-01" @default.
• W2331005864 modified "2023-10-01" @default.
• W2331005864 title "Semisynthetic .BETA.-lactam antibiotics. II. Effect on antibacterial activity of ureido N-substituents in the 6-((R)-2-(3-(3,4-dihydroxybenzoyl)-1-ureido)-2-phenylacetamido)penicillanic acids." @default.
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• W2331005864 doi "https://doi.org/10.7164/antibiotics.39.242" @default.
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