Matches in SemOpenAlex for { <https://semopenalex.org/work/W2331016799> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2331016799 abstract "A method of high-performance liquid chromatography was developed in order to study the pharmacokinetics of cisplatin (CDDP) administration by bronchial artery infusion (BAI). Following ultrafiltration of serum with centrisart I (mol. wt. cut off<10, 000), platinum chelation by N, N-diethyl-dithiocarbamate (DDTC), extraction with chloroform and separation on an octadecylsilane-bonded silica column (TSK gel ODS 120T, 4.6 I.D.×150 mm), the eluted components were detected by UV monitoring at 254 nm. The mobile phase consisted of methanol-chloroform-water (68: 3: 29). Nickel chloride was used as an internal standard.There was a linear relationship between the peak height ratio and the concentration of CDDP in the serum in the range of 0.1 to 10 μg/ml. The detection limit was 0.02 μg/ml (S/N=3) in serum. The overall analytical recovery of CDDP was 78.4-92.2% in the concentration in the range of 0.1 to 10 μg/ml.Serum concentrations of ultrafiltratable CDDP were determined by following 50 mg/body and 50 mg/m2 BAI of CDDP to lung cancer patients, and the effects of the two doses were compared. After BAI, the mean concentration of ultrafiltratable CDDP showed that the drugs behaved according to the rules of the one-compartment open model and the respective halflives were 27.75 min (50 mg/body) and 21.88 min (50 mg/m2), which were significantly different." @default.
- W2331016799 created "2016-06-24" @default.
- W2331016799 creator A5019706142 @default.
- W2331016799 creator A5047274916 @default.
- W2331016799 creator A5048397658 @default.
- W2331016799 creator A5055922202 @default.
- W2331016799 creator A5080535160 @default.
- W2331016799 date "1988-01-01" @default.
- W2331016799 modified "2023-10-02" @default.
- W2331016799 title "Serum pharmacokinetics of cisplatin by bronchial artery infusion in lung cancer patients." @default.
- W2331016799 doi "https://doi.org/10.5649/jjphcs1975.14.246" @default.
- W2331016799 hasPublicationYear "1988" @default.
- W2331016799 type Work @default.
- W2331016799 sameAs 2331016799 @default.
- W2331016799 citedByCount "0" @default.
- W2331016799 crossrefType "journal-article" @default.
- W2331016799 hasAuthorship W2331016799A5019706142 @default.
- W2331016799 hasAuthorship W2331016799A5047274916 @default.
- W2331016799 hasAuthorship W2331016799A5048397658 @default.
- W2331016799 hasAuthorship W2331016799A5055922202 @default.
- W2331016799 hasAuthorship W2331016799A5080535160 @default.
- W2331016799 hasBestOaLocation W23310167991 @default.
- W2331016799 hasConcept C112705442 @default.
- W2331016799 hasConcept C119128265 @default.
- W2331016799 hasConcept C126322002 @default.
- W2331016799 hasConcept C179998833 @default.
- W2331016799 hasConcept C185592680 @default.
- W2331016799 hasConcept C2776256026 @default.
- W2331016799 hasConcept C2776694085 @default.
- W2331016799 hasConcept C2778239845 @default.
- W2331016799 hasConcept C2781144210 @default.
- W2331016799 hasConcept C43617362 @default.
- W2331016799 hasConcept C50817676 @default.
- W2331016799 hasConcept C71924100 @default.
- W2331016799 hasConcept C98274493 @default.
- W2331016799 hasConceptScore W2331016799C112705442 @default.
- W2331016799 hasConceptScore W2331016799C119128265 @default.
- W2331016799 hasConceptScore W2331016799C126322002 @default.
- W2331016799 hasConceptScore W2331016799C179998833 @default.
- W2331016799 hasConceptScore W2331016799C185592680 @default.
- W2331016799 hasConceptScore W2331016799C2776256026 @default.
- W2331016799 hasConceptScore W2331016799C2776694085 @default.
- W2331016799 hasConceptScore W2331016799C2778239845 @default.
- W2331016799 hasConceptScore W2331016799C2781144210 @default.
- W2331016799 hasConceptScore W2331016799C43617362 @default.
- W2331016799 hasConceptScore W2331016799C50817676 @default.
- W2331016799 hasConceptScore W2331016799C71924100 @default.
- W2331016799 hasConceptScore W2331016799C98274493 @default.
- W2331016799 hasLocation W23310167991 @default.
- W2331016799 hasOpenAccess W2331016799 @default.
- W2331016799 hasPrimaryLocation W23310167991 @default.
- W2331016799 hasRelatedWork W1989553576 @default.
- W2331016799 hasRelatedWork W1997793566 @default.
- W2331016799 hasRelatedWork W2011622170 @default.
- W2331016799 hasRelatedWork W2043008913 @default.
- W2331016799 hasRelatedWork W2145566134 @default.
- W2331016799 hasRelatedWork W2347594295 @default.
- W2331016799 hasRelatedWork W2349330249 @default.
- W2331016799 hasRelatedWork W2352571879 @default.
- W2331016799 hasRelatedWork W2357989608 @default.
- W2331016799 hasRelatedWork W2366178766 @default.
- W2331016799 hasRelatedWork W2373940694 @default.
- W2331016799 hasRelatedWork W2377959917 @default.
- W2331016799 hasRelatedWork W2381052210 @default.
- W2331016799 hasRelatedWork W2382454464 @default.
- W2331016799 hasRelatedWork W2389434322 @default.
- W2331016799 hasRelatedWork W2391143939 @default.
- W2331016799 hasRelatedWork W2392314612 @default.
- W2331016799 hasRelatedWork W2564999215 @default.
- W2331016799 hasRelatedWork W2901831838 @default.
- W2331016799 hasRelatedWork W3031404725 @default.
- W2331016799 isParatext "false" @default.
- W2331016799 isRetracted "false" @default.
- W2331016799 magId "2331016799" @default.
- W2331016799 workType "article" @default.