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• W2331036198 abstract "Event Abstract Back to Event Exudation of antioxidants to the surface of medical devices: Impact on biocompatibility in the case of polyurethane used in implantable catheters Micheal Nouman1, Johanna Saunier1*, Emile E. Jubeli1*, Margareth Renault2*, Jean-Marie Herry2, Marie-Noelle Bellon Fontaine2* and Najet Yagoubi1 1 paris 11 university, France 2 INRA AgroParisTech, France An important proportion of the implantable catheters are made of polyurethane (PU). Moreover, the catheters contain additives such as antioxidants or lubricants. The repartition of additives in the bulk polymer is governed by thermodynamic and diffusion kinetics. As these molecules are small, they have a high mobility and can migrate through the polymer matrix to the surface[1]. As a consequence, even if the concentration of these additives in the bulk is commonly less than 0.5 %, they can be present at a very high concentration on the surface and can thereby modify the surface properties[2],[3]. In this communication we will present the case of an implantable polyurethane-based catheter that can present blooming of additives on its surface. Films of various antioxidants were prepared by the spin-coating technique, and characterized in the amorphous state and after crystallization via a heating cycle. The roughness, the effect of the film thickness and the crystallization morphology were examined by atomic force microscope. The hydrophobicity of these films was determined. Bacterial adhesion tests were realized using staphylococcus aureus, a bacterium often implicated in nosocomial diseases. The cytotoxicity of antioxidants in a soluble state at different concentrations and under the form of spincoated films of different thicknesses as well as the cytotoxicity of polyurethane films containing these antioxidants have been studied. The adhesion ability of the endothelial cells and the viability of adhered cells were evaluated and we try to correlate these results to the physical properties of the surface (hydrophobicity, topography,…). The growth of endothelial cells of human umbilical cord vein on the surface of polyurethane films containing these antioxidants in the amorphous and crystalline state was followed during 96 hours by microscopy. The adhesion of monocytes (THP1 line) differentiated into macrophages was followed in the same way. The study of the pro-inflammatory cytokines production by macrophages in contact with these films has been carried out also. References:[1] R. Spatafore, L.T. Pearson, Migration and blooming of stabilizing antioxidant in polypropylene, Polym. Eng. Sci. 31 (1991) 1610–1617[2] O. Mrad, J. Saunier, C. Aymes-Chodur, V. Rosilio, S. Bouttier, F. Agnely, et al., Amultiscale approach to assess the complex surface of polyurethane catheters and the effects of a new plasma decontamination treatment on the surface properties, Microsc. Microanal. 16 (2010) 764–778.[3] O. Mrad, J. Saunier, C. Aymes-Chodur, V. Mazel, V. Rosilio, F. Agnely, et al., Aging of amedical device surface following cold plasma treatment: influence of low molecular weight compounds on surface recovery, Eur. Polym. J. 47 (2011) 2403–2413. Keywords: cytokine, Biocompatibility, polymer, surface topolography Conference: 10th World Biomaterials Congress, Montréal, Canada, 17 May - 22 May, 2016. Presentation Type: Poster Topic: Role of biomaterials in inflammation Citation: Nouman M, Saunier J, Jubeli EE, Renault M, Herry J, Bellon Fontaine M and Yagoubi N (2016). Exudation of antioxidants to the surface of medical devices: Impact on biocompatibility in the case of polyurethane used in implantable catheters. Front. Bioeng. Biotechnol. Conference Abstract: 10th World Biomaterials Congress. doi: 10.3389/conf.FBIOE.2016.01.01731 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 27 Mar 2016; Published Online: 30 Mar 2016. * Correspondence: Dr. Johanna Saunier, paris 11 university, Chatenay Malabry, France, johanna.saunier@u-psud.fr Dr. Emile E Jubeli, paris 11 university, Chatenay Malabry, France, emile.jubeli@u-psud.fr Dr. Margareth Renault, INRA AgroParisTech, Massy, France, margareth.renault@jouy.inra.fr Dr. Marie-Noelle Bellon Fontaine, INRA AgroParisTech, Massy, France, marie-noelle.bellon-fontaine@agroparistech.fr Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Micheal Nouman Johanna Saunier Emile E Jubeli Margareth Renault Jean-Marie Herry Marie-Noelle Bellon Fontaine Najet Yagoubi Google Micheal Nouman Johanna Saunier Emile E Jubeli Margareth Renault Jean-Marie Herry Marie-Noelle Bellon Fontaine Najet Yagoubi Google Scholar Micheal Nouman Johanna Saunier Emile E Jubeli Margareth Renault Jean-Marie Herry Marie-Noelle Bellon Fontaine Najet Yagoubi PubMed Micheal Nouman Johanna Saunier Emile E Jubeli Margareth Renault Jean-Marie Herry Marie-Noelle Bellon Fontaine Najet Yagoubi Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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• W2331036198 title "Exudation of antioxidants to the surface of medical devices: Impact on biocompatibility in the case of polyurethane used in implantable catheters" @default.
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