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• W2331068605 abstract "Animals must be capable of sensing hazardous temperatures to avoid physical injury. Recent progress has revealed the molecular mechanisms underlying this capability. This essential function requires a subset of the Transient Receptor Potential (TRP) channel family in both mammals and Drosophila. We recently showed that a Drosophila TRP channel, dubbed Painless, possesses heat sensitivity that is essential for avoidance of noxious heat. The temperature threshold for Painless activation is consistent with the temperatures that cause avoidance behaviors in vivo, indicating that Painless acts as a primary noxious heat detector in Drosophila. In this review, we summarize the properties of temperature-sensitive TRP channels, including Painless, in fruit flies." @default.
• W2331068605 created "2016-06-24" @default.
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• W2331068605 date "2009-03-01" @default.
• W2331068605 modified "2023-10-03" @default.
• W2331068605 title "A temperature-sensitive TRP ion channel, Painless, functions as a noxious heat sensor in fruit flies" @default.
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• W2331068605 doi "https://doi.org/10.4161/cib.7708" @default.
• W2331068605 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2686375" @default.
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